| Item type |
紀要論文(ELS) / Departmental Bulletin Paper(1) |
| 公開日 |
2010-12-01 |
| タイトル |
|
|
タイトル |
マキバブラシノキ Callistemon rigidusのマトリックスメタロプロテアーゼ-2阻害作用 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
Constituent of Callistemon rigidus Showing an Inhibitory Effect on Activated Matrix Metalloproteinase-2 |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Callistemon rigidus ; piceatannol ; matrix matalloproteinase-2 ; rat lung ; gelatin zymograpy |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者名 |
佐々木, 健郎
小林, 匡子
川島, 美香
佐藤, 紘子
吉﨑, 文彦
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The influence of Callistemon rigidus (Myrtaceae) on rat lung activated matrix matalloproteinase-2 (MMP-2) was examined. Methanol extracts from stem and fruit showed inhibitory effects on MMP-2.Activation was induced by p-aminophenylmercuric acetate,and inhibition was measired by using sodium dodecyl sulfate polyacrylamid gel electrophoresis gelatin zymography.The IC50 values were 2.96 and 32.0mg/mL,respectively. Piceatannol was isolated as the active constituent from the stem of this plant,and its IC50 value was 757.1μM. The usefulness of Callistemon rigidus as a supply source of piceatannol is noted,and utility of piceatannol for the investigation of the inhibition of activated MMP-2 was also expected for the prevention and treatment of various diseases concerned with excess activation of MMP. |
|
言語 |
en |
| 書誌情報 |
ja : 東北薬科大学研究誌
en : Journal of Tohoku Pharmaceutical University
号 57,
p. 61-65,
発行日 2010-12
|
| 雑誌書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1149311X |
KJ00007291389 (935.3 kB)
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