{"created":"2023-06-20T13:11:03.833488+00:00","id":76,"links":{},"metadata":{"_buckets":{"deposit":"b3de6f29-7e94-462d-91f5-fea8c8ff2c69"},"_deposit":{"created_by":15,"id":"76","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"76"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000076","sets":["3:14"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"57","bibliographicPageEnd":"65","bibliographicPageStart":"61","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐々木, 健郎","creatorNameLang":"ja"},{"creatorName":"ササキ, ケンロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Kenroh","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小林, 匡子","creatorNameLang":"ja"},{"creatorName":"コバヤシ, キョウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Kyoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"川島, 美香","creatorNameLang":"ja"},{"creatorName":"カワシマ, ミカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawashima, Mika","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 紘子","creatorNameLang":"ja"},{"creatorName":"サトウ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Hiroko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉﨑, 文彦","creatorNameLang":"ja"},{"creatorName":"ヨシザキ, フミヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshizaki, Fumihiko","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"The influence of Callistemon rigidus (Myrtaceae) on rat lung activated matrix matalloproteinase-2 (MMP-2) was examined. Methanol extracts from stem and fruit showed inhibitory effects on MMP-2.Activation was induced by p-aminophenylmercuric acetate,and inhibition was measired by using sodium dodecyl sulfate polyacrylamid gel electrophoresis gelatin zymography.The IC50 values were 2.96 and 32.0mg/mL,respectively. Piceatannol was isolated as the active constituent from the stem of this plant,and its IC50 value was 757.1μM. The usefulness of Callistemon rigidus as a supply source of piceatannol is noted,and utility of piceatannol for the investigation of the inhibition of activated MMP-2 was also expected for the prevention and treatment of various diseases concerned with excess activation of MMP.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2010-12-01"}],"displaytype":"detail","filename":"KJ00007291389.pdf","filesize":[{"value":"935.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00007291389","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/76/files/KJ00007291389.pdf"},"version_id":"41e35bbf-a359-4702-a27c-852331aa1619"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Callistemon rigidus ; piceatannol ; matrix matalloproteinase-2 ; rat lung ; gelatin zymograpy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マキバブラシノキ Callistemon rigidusのマトリックスメタロプロテアーゼ-2阻害作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マキバブラシノキ Callistemon rigidusのマトリックスメタロプロテアーゼ-2阻害作用","subitem_title_language":"ja"},{"subitem_title":"Constituent of Callistemon rigidus Showing an Inhibitory Effect on Activated Matrix Metalloproteinase-2","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["14"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-12-01"},"publish_date":"2010-12-01","publish_status":"0","recid":"76","relation_version_is_last":true,"title":["マキバブラシノキ Callistemon rigidusのマトリックスメタロプロテアーゼ-2阻害作用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:46:12.662868+00:00"}