{"_buckets": {"deposit": "3ee03dae-6f66-4037-9408-a4fcf6cd12ec"}, "_deposit": {"created_by": 15, "id": "75", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "75"}, "status": "published"}, "_oai": {"id": "oai:tohoku-mpu.repo.nii.ac.jp:00000075", "sets": ["14"]}, "author_link": [], "control_number": "75", "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "57", "bibliographicPageEnd": "59", "bibliographicPageStart": "55", "bibliographic_titles": [{"bibliographic_title": "東北薬科大学研究誌", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Journal of Tohoku Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "山本, 学", "creatorNameLang": "ja"}, {"creatorName": "ヤマモト, マナブ", "creatorNameLang": "ja-Kana"}, {"creatorName": "YAMAMOTO, MANABU", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "柴田, 信之", "creatorNameLang": "ja"}, {"creatorName": "シバタ, ノブユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "SHIBATA, NOBUYUKI", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "大川, 喜男", "creatorNameLang": "ja"}, {"creatorName": "オオカワ, ヨシオ", "creatorNameLang": "ja-Kana"}, {"creatorName": "OKAWA, YOSHIO", "creatorNameLang": "en"}]}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "We made experiments to investigate the effect of Candida albicans mannan in the brain of mice with Candidasis and obtained the following results.The intracerebral injection of mannnan induced fatal event(s) in mice.The mannan also stimulated the release of proinflammatory mediators,nitric oxide (NO),tumor necrosis factor-α (TNF-α),interleukin-1β (IL-1β),and interleukin-6(IL-6),in the astrocytes.From these results, we speculate that the mannan in the brain induces the fatal event(s) to mice via the potent production of the proinflammatory mediators(NO,TNF-α,IL-1β,and IL-6).", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1149311X", "subitem_source_identifier_type": "NCID"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2010-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00007291300.pdf", "filesize": [{"value": "941.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 941100.0, "url": {"label": "KJ00007291300", "objectType": "fulltext", "url": "https://tohoku-mpu.repo.nii.ac.jp/record/75/files/KJ00007291300.pdf"}, "version_id": "02ba7c08-57b1-402d-8363-e2693fb21afb"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Candida albicans ; mannan ; astrocyte ; inflammatory mediators", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Candida albicansマンナンによるアストロサイトからの炎症性因子の産生", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Candida albicansマンナンによるアストロサイトからの炎症性因子の産生", "subitem_title_language": "ja"}, {"subitem_title": "Production of Proinflammatory Mediators from Astrocytesby Candida albicans Mannan", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "15", "path": ["14"], "permalink_uri": "https://tohoku-mpu.repo.nii.ac.jp/records/75", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-12-01"}, "publish_date": "2010-12-01", "publish_status": "0", "recid": "75", "relation": {}, "relation_version_is_last": true, "title": ["Candida albicansマンナンによるアストロサイトからの炎症性因子の産生"], "weko_shared_id": -1}