@article{oai:tohoku-mpu.repo.nii.ac.jp:00000075, author = {山本, 学 and Yamamoto, Manabu and 柴田, 信之 and Shibata, Nobuyuki and 大川, 喜男 and Okawa, Yoshio}, issue = {57}, journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University}, month = {Dec}, note = {We made experiments to investigate the effect of Candida albicans mannan in the brain of mice with Candidasis and obtained the following results.The intracerebral injection of mannnan induced fatal event(s) in mice.The mannan also stimulated the release of proinflammatory mediators,nitric oxide (NO),tumor necrosis factor-α (TNF-α),interleukin-1β (IL-1β),and interleukin-6(IL-6),in the astrocytes.From these results, we speculate that the mannan in the brain induces the fatal event(s) to mice via the potent production of the proinflammatory mediators(NO,TNF-α,IL-1β,and IL-6).}, pages = {55--59}, title = {Candida albicansマンナンによるアストロサイトからの炎症性因子の産生}, year = {2010}, yomi = {ヤマモト, マナブ and シバタ, ノブユキ and オオカワ, ヨシオ} }