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  1. 研究誌
  2. 第61号

嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用

https://tohoku-mpu.repo.nii.ac.jp/records/589
https://tohoku-mpu.repo.nii.ac.jp/records/589
b23b423b-578b-4a9b-9606-b12a6deadd74
名前 / ファイル ライセンス アクション
61(41−46).pdf 嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用 (1.5 MB)
license.icon
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-04-23
タイトル
言語 ja
タイトル 嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用
タイトル
言語 en
タイトル Fluvoxamine ameliorates cognitive dysfunctions in olfactory bulbectomized mice
言語
言語 jpn
キーワード
言語 en
主題Scheme Other
主題 cognitive dysfunction
キーワード
言語 en
主題Scheme Other
主題 olfactory bulbectomy
キーワード
言語 en
主題Scheme Other
主題 fluvoxamine
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
著者 中川西, 修

× 中川西, 修

WEKO 2697

ja 中川西, 修

ja-Kana ナカガワサイ, オサム

en NAKAGAWASAI, OSAMU

Search repository
吉田, 文

× 吉田, 文

WEKO 2698

ja 吉田, 文

ja-Kana ヨシダ, アヤ

en YOSHIDA, AYA

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高橋, 浩平

× 高橋, 浩平

WEKO 2699

ja 高橋, 浩平

ja-Kana タカハシ, コウヘイ

en TAKAHASHI, KOHEI

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根本, 亙

× 根本, 亙

WEKO 2700

ja 根本, 亙

ja-Kana ネモト, ワタル

en NEMOTO, WATARU

Search repository
八百板, 富紀枝

× 八百板, 富紀枝

WEKO 2701

ja 八百板, 富紀枝

ja-Kana ヤオイタ, フキエ

en YAOITA, FUKIE

Search repository
只野, 武

× 只野, 武

WEKO 2702

ja 只野, 武

ja-Kana タダノ, タケシ

en TADANO, TAKESHI

Search repository
丹野, 孝一

× 丹野, 孝一

WEKO 2703

ja 丹野, 孝一

ja-Kana タンノ, コウイチ

en TAN-NO, KOICHI

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抄録
内容記述タイプ Abstract
内容記述 This study was undertaken to examine the effect of the selective serotonin reuptake inhibitor(ssRi)fluvoxamine on cognitive dysfunctions in olfactory bulbectomized(OBX)mice. in the novel object recognition test, OBX mice significantly decreased the exploratory preference in the retention session, but not in the training session. OBX-induced cognitive dysfunctions were significantly improved by chronic(3-week)administration of fluvoxamine(30 mg/kg/day), but not acute. The present study suggests that chronic fluvoxamine treatment may ameliorate OBX-induced cognitive dysfunctions via a mechanism involving enhancement of synaptic plasticityrelated signaling. Therefore, ssRi such as fluvoxamine would be potential therapeutic drugs for the treatment of the cognitive dysfunctions of alzheimer s disease.
言語 en
書誌情報 ja : 東北薬科大学研究誌
en : Journal of Tohoku Pharmaceutical University

号 61, p. 41-46, 発行日 2014-12
出版者
言語 ja
出版者 東北薬科大学
ISSN
収録物識別子タイプ PISSN
収録物識別子 1345-157X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA1149311X
権利
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en
権利情報 Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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