{"created":"2023-06-20T13:11:23.813486+00:00","id":589,"links":{},"metadata":{"_buckets":{"deposit":"12141f93-3cdb-4710-9648-2edac24eccdc"},"_deposit":{"created_by":15,"id":"589","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"589"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000589","sets":["3:43"]},"author_link":[],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"61","bibliographicPageEnd":"46","bibliographicPageStart":"41","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study was undertaken to examine the effect of the selective serotonin reuptake inhibitor（ssRi）fluvoxamine on cognitive dysfunctions in olfactory bulbectomized（OBX）mice. in the novel object recognition test, OBX mice significantly decreased the exploratory preference in the retention session, but not in the training session. OBX-induced cognitive dysfunctions were significantly improved by chronic（3-week）administration of fluvoxamine（30 mg/kg/day）, but not acute. The present study suggests that chronic fluvoxamine treatment may ameliorate OBX-induced cognitive dysfunctions via a mechanism involving enhancement of synaptic plasticityrelated signaling. Therefore, ssRi such as fluvoxamine would be potential therapeutic drugs for the treatment of the cognitive dysfunctions of alzheimer s disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北薬科大学","subitem_publisher_language":"ja"}]},"item_10002_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1345-157X","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中川西, 修","creatorNameLang":"ja"},{"creatorName":"ナカガワサイ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"Nakagawasai, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉田, 文","creatorNameLang":"ja"},{"creatorName":"ヨシダ, アヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Aya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"高橋, 浩平","creatorNameLang":"ja"},{"creatorName":"タカハシ, コウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Kohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"根本, 亙","creatorNameLang":"ja"},{"creatorName":"ネモト, ワタル","creatorNameLang":"ja-Kana"},{"creatorName":"Nemoto, Wataru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"八百板, 富紀枝","creatorNameLang":"ja"},{"creatorName":"ヤオイタ, フキエ","creatorNameLang":"ja-Kana"},{"creatorName":"Yaoita, Fukie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"只野, 武","creatorNameLang":"ja"},{"creatorName":"タダノ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tadano, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"丹野, 孝一","creatorNameLang":"ja"},{"creatorName":"タンノ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Tan-no, Koichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-04-23"}],"displaytype":"detail","filename":"61(41−46).pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/589/files/61(41−46).pdf"},"version_id":"7d8bda5c-e692-4e42-973f-dd96f00436d3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cognitive dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"olfactory bulbectomy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fluvoxamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用","subitem_title_language":"ja"},{"subitem_title":"Fluvoxamine ameliorates cognitive dysfunctions in olfactory bulbectomized mice","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["43"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-04-23"},"publish_date":"2015-04-23","publish_status":"0","recid":"589","relation_version_is_last":true,"title":["嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:42:50.821330+00:00"}