@article{oai:tohoku-mpu.repo.nii.ac.jp:00000589,
 author = {中川西, 修 and Nakagawasai, Osamu and 吉田, 文 and Yoshida, Aya and 高橋, 浩平 and Takahashi, Kohei and 根本, 亙 and Nemoto, Wataru and 八百板, 富紀枝 and Yaoita, Fukie and 只野, 武 and Tadano, Takeshi and 丹野, 孝一 and Tan-no, Koichi},
 issue = {61},
 journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University},
 month = {Dec},
 note = {This study was undertaken to examine the effect of the selective serotonin reuptake inhibitor（ssRi）fluvoxamine on cognitive dysfunctions in olfactory bulbectomized（OBX）mice. in the novel object recognition test, OBX mice significantly decreased the exploratory preference in the retention session, but not in the training session. OBX-induced cognitive dysfunctions were significantly improved by chronic（3-week）administration of fluvoxamine（30 mg/kg/day）, but not acute. The present study suggests that chronic fluvoxamine treatment may ameliorate OBX-induced cognitive dysfunctions via a mechanism involving enhancement of synaptic plasticityrelated signaling. Therefore, ssRi such as fluvoxamine would be potential therapeutic drugs for the treatment of the cognitive dysfunctions of alzheimer s disease.},
 pages = {41--46},
 title = {嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用},
 year = {2014},
 yomi = {ナカガワサイ, オサム and ヨシダ, アヤ and タカハシ, コウヘイ and ネモト, ワタル and ヤオイタ, フキエ and タダノ, タケシ and タンノ, コウイチ}
}