{"_buckets": {"deposit": "7f300fc1-d4bd-4d78-a5b2-a59d80b836db"}, "_deposit": {"created_by": 15, "id": "54", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "54"}, "status": "published"}, "_oai": {"id": "oai:tohoku-mpu.repo.nii.ac.jp:00000054", "sets": ["15"]}, "author_link": [], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "50", "bibliographicPageEnd": "184", "bibliographicPageStart": "179", "bibliographic_titles": [{"bibliographic_title": "東北薬科大学研究誌", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Journal of Tohoku Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "結城, 正幸", "creatorNameLang": "ja"}, {"creatorName": "ユウキ, マサユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Yuhki, Masayuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "渡邉, 廣行", "creatorNameLang": "ja"}, {"creatorName": "ワタナベ, ヒロユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Watanabe, Hiroyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "岩田, 陽子", "creatorNameLang": "ja"}, {"creatorName": "イワタ, ヨウコ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Iwata, Yoko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "中山, 大助", "creatorNameLang": "ja"}, {"creatorName": "ナカヤマ, ダイスケ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Nakayama, Daisuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "照井, 潤", "creatorNameLang": "ja"}, {"creatorName": "テルイ, ジュン", "creatorNameLang": "ja-Kana"}, {"creatorName": "Terui, Jun", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "櫻田, 忍", "creatorNameLang": "ja"}, {"creatorName": "サクラダ, シノブ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sakurada, Shinobu", "creatorNameLang": "en"}]}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "Intrathecal (i.t.) administration of substance P or capsaicin elicited a characteristic behavioural response consisting of scratching, biting and licking (SBL) in mice. The behavioural response induced by substance P or capsaicin was almost completely inhibited by simultaneous i. t. injection of [D-Ala^2, MePhe^4, Gly(ol)^5] enkephalin (DAMGO), H-Tyr-D-Arg-Phe-β-Ala-OH (TAPA) or H-Tyr-D-Arg-Phe-β-Ala-NH_2 (TAPA-NH_2). Pretreatment with naloxonazine significantly antagonized inhibitory action of TAPA-NH_2 on substance Pinduced SBL behavioural response without antagonistic effect against DAMGO and TAPA, while antinociceptive effect of DAMGO, TAPA and TAPA-NH_2 was completely inhibited by the pretreatment with naloxone. TAPA-induced antinociception but not DAMGO-and TAPA-NH_2-induced antinociception on behavioural response produced by i. t. capsaicin was completely inhibited by the pretreatment with naloxonazine, whereas naloxone at a dose of 1 mg/kg s. c. completely antagonized the antinociceptive effect of i. t. co-administered TAPA, DAMGO- or TAPA-NH_2. These results led us to understanding of differential action mechanism of TAPA- and TAPA-NH_2-induced antinociception, as assayed by SBL behavioural response produced by both capsaicin and substance P.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1149311X", "subitem_source_identifier_type": "NCID"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2003-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004261049.pdf", "filesize": [{"value": "498.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 498600.0, "url": {"label": "KJ00004261049", "objectType": "fulltext", "url": "https://tohoku-mpu.repo.nii.ac.jp/record/54/files/KJ00004261049.pdf"}, "version_id": "e9584826-7e19-44e6-ad8f-9a8205f2e285"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "μ-opioid receptor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dermorphin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tetrapeptides", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "naloxonazine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "antinociception", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mouse", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Dermorphin analogueであるH-Tyr-D-Arg-Phe-β-Ala-OHおよびH-Tyr-D-Arg-Phe-β-Ala-NH_2によるcapsaicinおよびsubstance P誘発性SBL行動抑制の違いについて", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Dermorphin analogueであるH-Tyr-D-Arg-Phe-β-Ala-OHおよびH-Tyr-D-Arg-Phe-β-Ala-NH_2によるcapsaicinおよびsubstance P誘発性SBL行動抑制の違いについて", "subitem_title_language": "ja"}, {"subitem_title": "Differential Inhibitory Effects of Opioids, H-Tyr-D-Arg-Phe-β-Ala-OH and H-Tyr-D-Arg-Phe-β-Ala-NH_2 on Capsaicin-and Substance P-induced SBL Behaviour in Mice", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "15", "path": ["15"], "permalink_uri": "https://tohoku-mpu.repo.nii.ac.jp/records/54", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2003-12-01"}, "publish_date": "2003-12-01", "publish_status": "0", "recid": "54", "relation": {}, "relation_version_is_last": true, "title": ["Dermorphin analogueであるH-Tyr-D-Arg-Phe-β-Ala-OHおよびH-Tyr-D-Arg-Phe-β-Ala-NH_2によるcapsaicinおよびsubstance P誘発性SBL行動抑制の違いについて"], "weko_shared_id": -1}
Dermorphin analogueであるH-Tyr-D-Arg-Phe-β-Ala-OHおよびH-Tyr-D-Arg-Phe-β-Ala-NH_2によるcapsaicinおよびsubstance P誘発性SBL行動抑制の違いについて
https://tohoku-mpu.repo.nii.ac.jp/records/54
https://tohoku-mpu.repo.nii.ac.jp/records/54