{"created":"2023-06-20T13:11:02.602930+00:00","id":54,"links":{},"metadata":{"_buckets":{"deposit":"7f300fc1-d4bd-4d78-a5b2-a59d80b836db"},"_deposit":{"created_by":15,"id":"54","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"54"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000054","sets":["3:15"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"50","bibliographicPageEnd":"184","bibliographicPageStart":"179","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"結城, 正幸","creatorNameLang":"ja"},{"creatorName":"ユウキ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yuhki, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"渡邉, 廣行","creatorNameLang":"ja"},{"creatorName":"ワタナベ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岩田, 陽子","creatorNameLang":"ja"},{"creatorName":"イワタ, ヨウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Yoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中山, 大助","creatorNameLang":"ja"},{"creatorName":"ナカヤマ, ダイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakayama, Daisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"照井, 潤","creatorNameLang":"ja"},{"creatorName":"テルイ, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Terui, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"櫻田, 忍","creatorNameLang":"ja"},{"creatorName":"サクラダ, シノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakurada, Shinobu","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Intrathecal (i.t.) administration of substance P or capsaicin elicited a characteristic behavioural response consisting of scratching, biting and licking (SBL) in mice. The behavioural response induced by substance P or capsaicin was almost completely inhibited by simultaneous i. t. injection of [D-Ala^2, MePhe^4, Gly(ol)^5] enkephalin (DAMGO), H-Tyr-D-Arg-Phe-β-Ala-OH (TAPA) or H-Tyr-D-Arg-Phe-β-Ala-NH_2 (TAPA-NH_2). Pretreatment with naloxonazine significantly antagonized inhibitory action of TAPA-NH_2 on substance Pinduced SBL behavioural response without antagonistic effect against DAMGO and TAPA, while antinociceptive effect of DAMGO, TAPA and TAPA-NH_2 was completely inhibited by the pretreatment with naloxone. TAPA-induced antinociception but not DAMGO-and TAPA-NH_2-induced antinociception on behavioural response produced by i. t. capsaicin was completely inhibited by the pretreatment with naloxonazine, whereas naloxone at a dose of 1 mg/kg s. c. completely antagonized the antinociceptive effect of i. t. co-administered TAPA, DAMGO- or TAPA-NH_2. These results led us to understanding of differential action mechanism of TAPA- and TAPA-NH_2-induced antinociception, as assayed by SBL behavioural response produced by both capsaicin and substance P.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2003-12-01"}],"displaytype":"detail","filename":"KJ00004261049.pdf","filesize":[{"value":"498.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00004261049","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/54/files/KJ00004261049.pdf"},"version_id":"e9584826-7e19-44e6-ad8f-9a8205f2e285"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"μ-opioid receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dermorphin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tetrapeptides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"naloxonazine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antinociception","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dermorphin analogueであるH-Tyr-D-Arg-Phe-β-Ala-OHおよびH-Tyr-D-Arg-Phe-β-Ala-NH_2によるcapsaicinおよびsubstance P誘発性SBL行動抑制の違いについて","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dermorphin analogueであるH-Tyr-D-Arg-Phe-β-Ala-OHおよびH-Tyr-D-Arg-Phe-β-Ala-NH_2によるcapsaicinおよびsubstance P誘発性SBL行動抑制の違いについて","subitem_title_language":"ja"},{"subitem_title":"Differential Inhibitory Effects of Opioids, H-Tyr-D-Arg-Phe-β-Ala-OH and H-Tyr-D-Arg-Phe-β-Ala-NH_2 on Capsaicin-and Substance P-induced SBL Behaviour in Mice","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["15"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2003-12-01"},"publish_date":"2003-12-01","publish_status":"0","recid":"54","relation_version_is_last":true,"title":["Dermorphin analogueであるH-Tyr-D-Arg-Phe-β-Ala-OHおよびH-Tyr-D-Arg-Phe-β-Ala-NH_2によるcapsaicinおよびsubstance P誘発性SBL行動抑制の違いについて"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:54:28.862607+00:00"}