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オリゴアルギニンペプチドの細胞内移行におけるTrp 残基導入の影響
https://tohoku-mpu.repo.nii.ac.jp/records/590
https://tohoku-mpu.repo.nii.ac.jp/records/590655e4030-f55a-4d08-bf9c-26c506a34e93
名前 / ファイル | ライセンス | アクション |
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オリゴアルギニンペプチドの細胞内移行におけるTrp 残基導入の影響 (2.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||||||||
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公開日 | 2015-04-23 | |||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||
タイトル | オリゴアルギニンペプチドの細胞内移行におけるTrp 残基導入の影響 | |||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
タイトル | Effect of substituting tryptophan for arginine on the cellular uptake of oligo-arginine peptides | |||||||||||||||||||||||
言語 | ||||||||||||||||||||||||
言語 | jpn | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | oligo-arginine peptide | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | cell penetrating peptide | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | antimicrobial peptide | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | tryptophan | |||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
資源タイプ | departmental bulletin paper | |||||||||||||||||||||||
著者 |
小野寺, 智美
× 小野寺, 智美
× 佐藤, 寛之
× 安保, 明博
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抄録 | ||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||
内容記述 | Oligo-arginine peptides are short cationic peptides capable of traversing the plasma membranes of cells. In order to explore the effective substitutes Trp for Arg on the cellular uptake of oligo-arginine peptides, we designed and synthesized a series of Trp-containing analogues. All synthetic peptides did not show cytotoxicity on Jurkat cells at final concentration of 10μM.[Trp5]- and[Trp6]analogues exhibited moderate cellular uptake(about 75% of octaarginine, R8C), and[Trp6,8]analogue exhibited similar or even slightly increased cellular uptake as compared to R8C. The other synthetic peptides were showed poor cellular uptake(less than 50%). A clear relationship was not observed between hydrophobicity and cellular uptake of the synthetic peptides. These results indicated that oligo-arginine pepitde was relatively tolerant to Trp insertion in the middle position but not in the N-terminal position. | |||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
書誌情報 |
ja : 東北薬科大学研究誌 en : Journal of Tohoku Pharmaceutical University 号 61, p. 47-53, 発行日 2014-12 |
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出版者 | ||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||
出版者 | 東北薬科大学 | |||||||||||||||||||||||
ISSN | ||||||||||||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||||||||||||
収録物識別子 | 1345-157X | |||||||||||||||||||||||
書誌レコードID | ||||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||||
収録物識別子 | AA1149311X | |||||||||||||||||||||||
権利 | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
権利情報Resource | https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en | |||||||||||||||||||||||
権利情報 | Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) | |||||||||||||||||||||||
著者版フラグ | ||||||||||||||||||||||||
出版タイプ | VoR | |||||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |