{"created":"2023-06-20T13:11:23.879106+00:00","id":590,"links":{},"metadata":{"_buckets":{"deposit":"68228a08-feec-4309-be80-6dd8c3b02780"},"_deposit":{"created_by":15,"id":"590","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"590"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000590","sets":["3:43"]},"author_link":[],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"61","bibliographicPageEnd":"53","bibliographicPageStart":"47","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oligo-arginine peptides are short cationic peptides capable of traversing the plasma membranes of cells. In order to explore the effective substitutes Trp for Arg on the cellular uptake of oligo-arginine peptides, we designed and synthesized a series of Trp-containing analogues. All synthetic peptides did not show cytotoxicity on Jurkat cells at final concentration of 10μM.［Trp5］- and［Trp6］analogues exhibited moderate cellular uptake（about 75% of octaarginine, R8C）, and［Trp6,8］analogue exhibited similar or even slightly increased cellular uptake as compared to R8C. The other synthetic peptides were showed poor cellular uptake（less than 50%）. A clear relationship was not observed between hydrophobicity and cellular uptake of the synthetic peptides. These results indicated that oligo-arginine pepitde was relatively tolerant to Trp insertion in the middle position but not in the N-terminal position.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北薬科大学","subitem_publisher_language":"ja"}]},"item_10002_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1345-157X","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小野寺, 智美","creatorNameLang":"ja"},{"creatorName":"オノデラ, サトミ","creatorNameLang":"ja-Kana"},{"creatorName":"Onodera, Satomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 寛之","creatorNameLang":"ja"},{"creatorName":"サトウ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"安保, 明博","creatorNameLang":"ja"},{"creatorName":"アンボ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ambo, Akihiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-04-23"}],"displaytype":"detail","filename":"61(47−53).pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"オリゴアルギニンペプチドの細胞内移行におけるTrp 残基導入の影響","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/590/files/61(47−53).pdf"},"version_id":"80a00265-a75f-4a11-9714-4a57dde857f8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"oligo-arginine peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell penetrating peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antimicrobial peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tryptophan","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"オリゴアルギニンペプチドの細胞内移行におけるTrp 残基導入の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オリゴアルギニンペプチドの細胞内移行におけるTrp 残基導入の影響","subitem_title_language":"ja"},{"subitem_title":"Effect of substituting tryptophan for arginine on the cellular uptake of oligo-arginine peptides","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["43"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-04-23"},"publish_date":"2015-04-23","publish_status":"0","recid":"590","relation_version_is_last":true,"title":["オリゴアルギニンペプチドの細胞内移行におけるTrp 残基導入の影響"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:42:50.433236+00:00"}