@article{oai:tohoku-mpu.repo.nii.ac.jp:00000590,
 author = {小野寺, 智美 and Onodera, Satomi and 佐藤, 寛之 and Sato, Hiroyuki and 安保, 明博 and Ambo, Akihiro},
 issue = {61},
 journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University},
 month = {Dec},
 note = {Oligo-arginine peptides are short cationic peptides capable of traversing the plasma membranes of cells. In order to explore the effective substitutes Trp for Arg on the cellular uptake of oligo-arginine peptides, we designed and synthesized a series of Trp-containing analogues. All synthetic peptides did not show cytotoxicity on Jurkat cells at final concentration of 10μM.［Trp5］- and［Trp6］analogues exhibited moderate cellular uptake（about 75% of octaarginine, R8C）, and［Trp6,8］analogue exhibited similar or even slightly increased cellular uptake as compared to R8C. The other synthetic peptides were showed poor cellular uptake（less than 50%）. A clear relationship was not observed between hydrophobicity and cellular uptake of the synthetic peptides. These results indicated that oligo-arginine pepitde was relatively tolerant to Trp insertion in the middle position but not in the N-terminal position.},
 pages = {47--53},
 title = {オリゴアルギニンペプチドの細胞内移行におけるTrp 残基導入の影響},
 year = {2014},
 yomi = {オノデラ, サトミ and サトウ, ヒロユキ and アンボ, アキヒロ}
}