{"_buckets": {"deposit": "43073e99-b977-4385-ad85-18e658b99aeb"}, "_deposit": {"created_by": 15, "id": "20", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "20"}, "status": "published"}, "_oai": {"id": "oai:tohoku-mpu.repo.nii.ac.jp:00000020", "sets": ["16"]}, "author_link": [], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "59", "bibliographicPageEnd": "49", "bibliographicPageStart": "45", "bibliographic_titles": [{"bibliographic_title": "東北薬科大学研究誌", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Journal of Tohoku Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "菅原, 栄紀", "creatorNameLang": "ja"}, {"creatorName": "スガワラ, シゲキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sugawara, Shigeki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "半田, 香奈絵", "creatorNameLang": "ja"}, {"creatorName": "ハンダ, カナエ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Handa, Kanae", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "任, 彰壎", "creatorNameLang": "ja"}, {"creatorName": "Im, Changhun", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "細野, 雅祐", "creatorNameLang": "ja"}, {"creatorName": "ホソノ, マサヒロ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Hosono, Masahiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "立田, 岳生", "creatorNameLang": "ja"}, {"creatorName": "タツタ, タケオ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Tatsuta, Takeo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "仁田, 一雄", "creatorNameLang": "ja"}, {"creatorName": "ニッタ, カズオ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Nitta, Kazuo", "creatorNameLang": "en"}]}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "Chemo-resistance to anti-cancer drugs is a major obstacle in efforts to develop a successful treatment of cancer.Resveratrol(RSV)facilitates the cellular uptake of doxorubicin through an induced down-regulation of multidrug resistance -associated protein-1(MRP1)expression.We studied whether RSV enhances the cytotoxic effect of vinblastine,vincristine,irinotecan,and etoposide in MRP1-expressing Burkitt\u0027s lymphoma Raji cells.Treatment with RSV caused decrease of cell viability in a time-and dose-dependent manner,and down-regulation of MRP1 expression in Raji cells.The cytotoxic effects of vinblastine,vincristine,and etoposide increased in RSV-pretreated Raji cells,but the effect of irinotecan did not change in the cells.These results indicate that RSV enhances the cellular uptake of vinblastine,and etoposide in Raji cell.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1149311X", "subitem_source_identifier_type": "NCID"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2012-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00008564059.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "KJ00008564059", "objectType": "fulltext", "url": "https://tohoku-mpu.repo.nii.ac.jp/record/20/files/KJ00008564059.pdf"}, "version_id": "a63aa74b-8696-4dc0-94f2-c5d0c395a343"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "multidrug resistance -associated protein-1", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "resveratrol", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "anti-cancer drug", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "レスベラトロール処理細胞における抗腫瘍薬の効果", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "レスベラトロール処理細胞における抗腫瘍薬の効果", "subitem_title_language": "ja"}, {"subitem_title": "Cytotoxie effect of anti-cancer drugs in resveratorol-treated cells", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "15", "path": ["16"], "permalink_uri": "https://tohoku-mpu.repo.nii.ac.jp/records/20", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2012-12-01"}, "publish_date": "2012-12-01", "publish_status": "0", "recid": "20", "relation": {}, "relation_version_is_last": true, "title": ["レスベラトロール処理細胞における抗腫瘍薬の効果"], "weko_shared_id": -1}
https://tohoku-mpu.repo.nii.ac.jp/records/20
https://tohoku-mpu.repo.nii.ac.jp/records/20