{"created":"2023-06-20T13:11:01.106889+00:00","id":20,"links":{},"metadata":{"_buckets":{"deposit":"43073e99-b977-4385-ad85-18e658b99aeb"},"_deposit":{"created_by":15,"id":"20","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"20"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000020","sets":["3:16"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"59","bibliographicPageEnd":"49","bibliographicPageStart":"45","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"菅原, 栄紀","creatorNameLang":"ja"},{"creatorName":"スガワラ, シゲキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugawara, Shigeki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"半田, 香奈絵","creatorNameLang":"ja"},{"creatorName":"ハンダ, カナエ","creatorNameLang":"ja-Kana"},{"creatorName":"Handa, Kanae","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"任, 彰壎","creatorNameLang":"ja"},{"creatorName":"Im, Changhun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"細野, 雅祐","creatorNameLang":"ja"},{"creatorName":"ホソノ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Hosono, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"立田, 岳生","creatorNameLang":"ja"},{"creatorName":"タツタ, タケオ","creatorNameLang":"ja-Kana"},{"creatorName":"Tatsuta, Takeo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"仁田, 一雄","creatorNameLang":"ja"},{"creatorName":"ニッタ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Nitta, Kazuo","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Chemo-resistance to anti-cancer drugs is a major obstacle in efforts to develop a successful treatment of cancer.Resveratrol(RSV)facilitates the cellular uptake of doxorubicin through an induced down-regulation of multidrug resistance -associated protein-1(MRP1)expression.We studied whether RSV enhances the cytotoxic effect of vinblastine,vincristine,irinotecan,and etoposide in MRP1-expressing Burkitt's lymphoma Raji cells.Treatment with RSV caused decrease of cell viability in a time-and dose-dependent manner,and down-regulation of MRP1 expression in Raji cells.The cytotoxic effects of vinblastine,vincristine,and etoposide increased in RSV-pretreated Raji cells,but the effect of irinotecan did not change in the cells.These results indicate that RSV enhances the cellular uptake of vinblastine,and etoposide in Raji cell.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-12-01"}],"displaytype":"detail","filename":"KJ00008564059.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00008564059","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/20/files/KJ00008564059.pdf"},"version_id":"a63aa74b-8696-4dc0-94f2-c5d0c395a343"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"multidrug resistance -associated protein-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"resveratrol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-cancer drug","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"レスベラトロール処理細胞における抗腫瘍薬の効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"レスベラトロール処理細胞における抗腫瘍薬の効果","subitem_title_language":"ja"},{"subitem_title":"Cytotoxie effect of anti-cancer drugs in resveratorol-treated cells","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["16"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-12-01"},"publish_date":"2012-12-01","publish_status":"0","recid":"20","relation_version_is_last":true,"title":["レスベラトロール処理細胞における抗腫瘍薬の効果"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:45:15.708463+00:00"}