@article{oai:tohoku-mpu.repo.nii.ac.jp:00000020,
 author = {菅原, 栄紀 and Sugawara, Shigeki and 半田, 香奈絵 and Handa, Kanae and 任, 彰壎 and Im, Changhun and 細野, 雅祐 and Hosono, Masahiro and 立田, 岳生 and Tatsuta, Takeo and 仁田, 一雄 and Nitta, Kazuo},
 issue = {59},
 journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University},
 month = {Dec},
 note = {Chemo-resistance to anti-cancer drugs is a major obstacle in efforts to develop a successful treatment of cancer.Resveratrol(RSV)facilitates the cellular uptake of doxorubicin through an induced down-regulation of multidrug resistance -associated protein-1(MRP1)expression.We studied whether RSV enhances the cytotoxic effect of vinblastine,vincristine,irinotecan,and etoposide in MRP1-expressing Burkitt's lymphoma Raji cells.Treatment with RSV caused decrease of cell viability in a time-and dose-dependent manner,and down-regulation of MRP1 expression in Raji cells.The cytotoxic effects of vinblastine,vincristine,and etoposide increased in RSV-pretreated Raji cells,but the effect of irinotecan did not change in the cells.These results indicate that RSV enhances the cellular uptake of vinblastine,and etoposide in Raji cell.},
 pages = {45--49},
 title = {レスベラトロール処理細胞における抗腫瘍薬の効果},
 year = {2012},
 yomi = {スガワラ, シゲキ and ハンダ, カナエ and ホソノ, マサヒロ and タツタ, タケオ and ニッタ, カズオ}
}