{"_buckets": {"deposit": "0bd77e08-6e90-4473-8e0c-f559d4eba4a4"}, "_deposit": {"created_by": 15, "id": "125", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "125"}, "status": "published"}, "_oai": {"id": "oai:tohoku-mpu.repo.nii.ac.jp:00000125", "sets": ["12"]}, "author_link": [], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "55", "bibliographicPageEnd": "109", "bibliographicPageStart": "99", "bibliographic_titles": [{"bibliographic_title": "東北薬科大学研究誌", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Journal of Tohoku Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小山内, 優", "creatorNameLang": "ja"}, {"creatorName": "オサナイ, ユウ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Osanai, Yuu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "菅野, 秀一", "creatorNameLang": "ja"}, {"creatorName": "カンノ, シュウイチ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Kanno, Syu-ichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "佐々木, 崇光", "creatorNameLang": "ja"}, {"creatorName": "ササキ, タカミツ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sasaki, Takamitsu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "平塚, 真弘", "creatorNameLang": "ja"}, {"creatorName": "ヒラツカ, マサヒロ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Hiratsuka, Masahiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "石川, 正明", "creatorNameLang": "ja"}, {"creatorName": "イシカワ, マサアキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Ishikawa, Masaaki", "creatorNameLang": "en"}]}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "We synthesized caffeic acid undecyl ester (CAUE),and found that it exhibited strong inhibitory effect of lipopolysaccharide (LPS) -induced nitric oxide (NO) production in murine macrophage-like RAW 264.7 cells.We examined the effect of CAUE on the expression inducible nitric oxide synthase (iNOS) in LPS-stimulated RAW 264.7 cells.Western blot analysis performed with specific anti-iNOS antibody showed that a decrease in NO was accompanied by a decrease in the level of iNOS protein with dose-dependent manner (CAUE:0.1~1.0μM).To clarify the mechanistic basis for CAUE\u0027s ability to inhibit the induction of iNOS,we examined the effect of CAUE on nuclear factor (NF)-κB,Inhibitor-κB (IκB) degradation and phosphorylation of extracellular-signaling regulated Kinases,ERK 1/2.CAUE potently suppressed the transcriptional activity of NF-κB,IκB degradation and activation of ERK.Since NF-κB was activated by following IκBα degradation,the recovery of IκBα protein indicating that CAUE inhibited the activation of degradation following NF-κB.These finding suggest that CAUE has the inhibitory effect on LPS-induced NO production and expression of iNOS in macrophage by the inhibition of IκB degradation and NF-κB activation,which may be mediated through blockage in the phospholylation ERK.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1149311X", "subitem_source_identifier_type": "NCID"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2008-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00007566559.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "KJ00007566559", "objectType": "fulltext", "url": "https://tohoku-mpu.repo.nii.ac.jp/record/125/files/KJ00007566559.pdf"}, "version_id": "30412308-bcec-4450-b6ec-2b15c3d8edd4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "caffeic acid undecyl ester;nitric oxide;inducible nitric oxide synthase;nuclear-factor-κB;RAW 264.7 macrophage", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "RAW 264.7細胞におけるLPSで誘導される誘導型NO合成酵素の発現に対するCaffeic Acid Undecyl Esterの阻害について", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "RAW 264.7細胞におけるLPSで誘導される誘導型NO合成酵素の発現に対するCaffeic Acid Undecyl Esterの阻害について", "subitem_title_language": "ja"}, {"subitem_title": "Inhibition of Lipopolysaccharide-induced Expression of Inducible Nitric Oxide Synthase by Caffeic Acid Undecyl Ester in RAW 264.7 Macrophages", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "15", "path": ["12"], "permalink_uri": "https://tohoku-mpu.repo.nii.ac.jp/records/125", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-12-01"}, "publish_date": "2008-12-01", "publish_status": "0", "recid": "125", "relation": {}, "relation_version_is_last": true, "title": ["RAW 264.7細胞におけるLPSで誘導される誘導型NO合成酵素の発現に対するCaffeic Acid Undecyl Esterの阻害について"], "weko_shared_id": -1}
RAW 264.7細胞におけるLPSで誘導される誘導型NO合成酵素の発現に対するCaffeic Acid Undecyl Esterの阻害について
https://tohoku-mpu.repo.nii.ac.jp/records/125
https://tohoku-mpu.repo.nii.ac.jp/records/125