{"created":"2023-06-20T13:11:05.954036+00:00","id":125,"links":{},"metadata":{"_buckets":{"deposit":"0bd77e08-6e90-4473-8e0c-f559d4eba4a4"},"_deposit":{"created_by":15,"id":"125","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"125"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000125","sets":["3:12"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"55","bibliographicPageEnd":"109","bibliographicPageStart":"99","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小山内, 優","creatorNameLang":"ja"},{"creatorName":"オサナイ, ユウ","creatorNameLang":"ja-Kana"},{"creatorName":"Osanai, Yuu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"菅野, 秀一","creatorNameLang":"ja"},{"creatorName":"カンノ, シュウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanno, Syu-ichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐々木, 崇光","creatorNameLang":"ja"},{"creatorName":"ササキ, タカミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Takamitsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"平塚, 真弘","creatorNameLang":"ja"},{"creatorName":"ヒラツカ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Hiratsuka, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"石川, 正明","creatorNameLang":"ja"},{"creatorName":"イシカワ, マサアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishikawa, Masaaki","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"We synthesized caffeic acid undecyl ester (CAUE),and found that it exhibited strong inhibitory effect of lipopolysaccharide (LPS) -induced nitric oxide (NO) production in murine macrophage-like RAW 264.7 cells.We examined the effect of CAUE on the expression inducible nitric oxide synthase (iNOS) in LPS-stimulated RAW 264.7 cells.Western blot analysis performed with specific anti-iNOS antibody showed that a decrease in NO was accompanied by a decrease in the level of iNOS protein with dose-dependent manner (CAUE:0.1～1.0μM).To clarify the mechanistic basis for CAUE's ability to inhibit the induction of iNOS,we examined the effect of CAUE on nuclear factor (NF)-κB,Inhibitor-κB (IκB) degradation and phosphorylation of extracellular-signaling regulated Kinases,ERK 1/2.CAUE potently suppressed the transcriptional activity of NF-κB,IκB degradation and activation of ERK.Since NF-κB was activated by following IκBα degradation,the recovery of IκBα protein indicating that CAUE inhibited the activation of degradation following NF-κB.These finding suggest that CAUE has the inhibitory effect on LPS-induced NO production and expression of iNOS in macrophage by the inhibition of IκB degradation and NF-κB activation,which may be mediated through blockage in the phospholylation ERK.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2008-12-01"}],"displaytype":"detail","filename":"KJ00007566559.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00007566559","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/125/files/KJ00007566559.pdf"},"version_id":"30412308-bcec-4450-b6ec-2b15c3d8edd4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"caffeic acid undecyl ester;nitric oxide;inducible nitric oxide synthase;nuclear-factor-κB;RAW 264.7 macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"RAW 264.7細胞におけるLPSで誘導される誘導型NO合成酵素の発現に対するCaffeic Acid Undecyl Esterの阻害について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RAW 264.7細胞におけるLPSで誘導される誘導型NO合成酵素の発現に対するCaffeic Acid Undecyl Esterの阻害について","subitem_title_language":"ja"},{"subitem_title":"Inhibition of Lipopolysaccharide-induced Expression of Inducible Nitric Oxide Synthase by Caffeic Acid Undecyl Ester in RAW 264.7 Macrophages","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["12"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-12-01"},"publish_date":"2008-12-01","publish_status":"0","recid":"125","relation_version_is_last":true,"title":["RAW 264.7細胞におけるLPSで誘導される誘導型NO合成酵素の発現に対するCaffeic Acid Undecyl Esterの阻害について"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:47:36.596559+00:00"}