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青森県で採集した水圏由来糸状菌からの protein tyrosine phosphatase 1B 阻害剤の探索
https://tohoku-mpu.repo.nii.ac.jp/records/588
https://tohoku-mpu.repo.nii.ac.jp/records/588ddfd2067-ff95-4150-a00b-7f05ec646dfe
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-04-23 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 青森県で採集した水圏由来糸状菌からの protein tyrosine phosphatase 1B 阻害剤の探索 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Quest of protein tyrosine phosphatase 1B inhibitors from aquatic fungi collected in Aomori | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | PTP1B inhibitor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | marine-derived fungus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Trichoderma sp. | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | α-pyrone deriveative | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
千田, 一慶
× 千田, 一慶× 齊藤, 亮× 山﨑, 寛之× 菅野, 秀一× 石川, 正明× 浪越, 通夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the course of our studies on the bioactive metabolites of aquatic fungi, we have tested the inhibitory activity on the culture broths of 21 fungal strains isolated from marine and freshwater(lake)environments against protein tyrosine phosphatase(PTP)1B, an important target enzyme for the treatment of typeⅡ diabetes and obesity. The ethyl acetate extracts from the culture broths of five fungal strains inhibited the PTP1B activity. Bioassayguided isolation from the extract of a marine-derived Trichoderma sp. strain TPU1239 yielded two knownα-pyrone derivatives, 6[-(E)-hept-1-enyl]-α-pyrone(1)and 6-n-pentyl-α-pyrone(2)as PTP1B inhibitors. The structures of 1 and 2 were identified on the basis of their spectroscopic data. Compound 1 showed an inhibitory activity against PTP1B with an iC50 value of 32.4μm. This is the first time to report the PTP1B inhibitory activity for compounds 1 and 2. moreover, compound 1 did not inhibit the cell proliferation of the human hepatoma huh-7 cells. a hepatocyte is one of the locations of PTP1B, and huh-7 cells are used for the study on the mechanism of action for PTP1B inhibitors. | |||||
言語 | en | |||||
書誌情報 |
ja : 東北薬科大学研究誌 en : Journal of Tohoku Pharmaceutical University 号 61, p. 35-39, 発行日 2014-12 |
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出版者 | ||||||
言語 | ja | |||||
出版者 | 東北薬科大学 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1345-157X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1149311X | |||||
権利 | ||||||
言語 | en | |||||
権利情報Resource | https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en | |||||
権利情報 | Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |