{"_buckets": {"deposit": "f38ff4e4-e32e-43c6-a985-1610a09c2c9e"}, "_deposit": {"created_by": 15, "id": "53", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "53"}, "status": "published"}, "_oai": {"id": "oai:tohoku-mpu.repo.nii.ac.jp:00000053", "sets": ["15"]}, "author_link": [], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "50", "bibliographicPageEnd": "178", "bibliographicPageStart": "173", "bibliographic_titles": [{"bibliographic_title": "東北薬科大学研究誌", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Journal of Tohoku Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "結城, 正幸", "creatorNameLang": "ja"}, {"creatorName": "ユウキ, マサユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Yuhki, Masayuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "溝口, 広一", "creatorNameLang": "ja"}, {"creatorName": "ミゾグチ, ヒロカズ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Mizoguchi, Hirokazu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "渡邉, 廣行", "creatorNameLang": "ja"}, {"creatorName": "ワタナベ, ヒロユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Watanabe, Hiroyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "林, 貴史", "creatorNameLang": "ja"}, {"creatorName": "ハヤシ, タカフミ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Hayashi, Takafumi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "櫻田, 誓", "creatorNameLang": "ja"}, {"creatorName": "サクラダ, チカイ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sakurada, Chikai", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "米澤, 章彦", "creatorNameLang": "ja"}, {"creatorName": "ヨネザワ, アキヒコ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Yonezawa, Akihiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "櫻田, 司", "creatorNameLang": "ja"}, {"creatorName": "サクラダ, ツカサ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sakurada, Tsukasa", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "櫻田, 忍", "creatorNameLang": "ja"}, {"creatorName": "サクラダ, シノブ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sakurada, Shinobu", "creatorNameLang": "en"}]}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "Involvement of μ1-opioid receptor on the antinociception induced by dermorphin tetrapeptide analogues Try-D-Arg-Phe-β-Ala (TAPA) and Tyr-D-Arg-Phe-β-Ala-NH_2 (TAPA-NH_2) were determined in mice, using a tail-pressure test and formalin test. TAPA and TAPA-NH_2 injected i. c. v. and i. t. produced dose-dependent antinociception in both assays. In the tail-pressure test, the antinociception induced by i. c. v. and i. t. injected TAPA, but not TAPA-NH_2, was significantly attenuated by the pretreatment with naloxonazine, selective antagonist for μ1-opioid receptor. Moreover, naloxonazine also significantly attenuated the antinociception induced by i. c. v. injected TAPA, but not TAPA-NH_2 in formalin test. In contrast, the antinociception induced by both TAPA and TAPA-NH_2 given i. t. was significantly attenuated by the pretreatment with naloxonazine in formalin test. The present results suggest that TAPA and TAPA-NH_2 should be considered to be selective agonist for μ1-and μ2-opioid receptors, respectively. The C-terminal amidation may be the critical portion for TAPA-NH_2 to distinguish μ1-and μ2-opioid receptors.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1149311X", "subitem_source_identifier_type": "NCID"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2003-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004261048.pdf", "filesize": [{"value": "588.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 588000.0, "url": {"label": "KJ00004261048", "objectType": "fulltext", "url": "https://tohoku-mpu.repo.nii.ac.jp/record/53/files/KJ00004261048.pdf"}, "version_id": "b3fd3748-4f9d-4252-99cd-6705f1396294"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "μ-opioid receptor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dermorphin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tetrapeptides", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "naloxonazine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "antinociception", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mouse", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Dermorphin tetrapeptide誘導体Tyr-D-Arg-Phe-β-AlaおよびTyr-D-Arg-Phe-β-Ala-NH_2の鎮痛作用発現におけるμ1受容体の関与", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Dermorphin tetrapeptide誘導体Tyr-D-Arg-Phe-β-AlaおよびTyr-D-Arg-Phe-β-Ala-NH_2の鎮痛作用発現におけるμ1受容体の関与", "subitem_title_language": "ja"}, {"subitem_title": "Differential Involvement of μ1-Opioid Receptor on the Antinociception Induced by Dermorphin Tetrapeptide Analogues, Tyr-D-Arg-Phe-β-Ala and Tyr-D-Arg-Phe-β-Ala-NH_2", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "15", "path": ["15"], "permalink_uri": "https://tohoku-mpu.repo.nii.ac.jp/records/53", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2003-12-01"}, "publish_date": "2003-12-01", "publish_status": "0", "recid": "53", "relation": {}, "relation_version_is_last": true, "title": ["Dermorphin tetrapeptide誘導体Tyr-D-Arg-Phe-β-AlaおよびTyr-D-Arg-Phe-β-Ala-NH_2の鎮痛作用発現におけるμ1受容体の関与"], "weko_shared_id": -1}
Dermorphin tetrapeptide誘導体Tyr-D-Arg-Phe-β-AlaおよびTyr-D-Arg-Phe-β-Ala-NH_2の鎮痛作用発現におけるμ1受容体の関与
https://tohoku-mpu.repo.nii.ac.jp/records/53
https://tohoku-mpu.repo.nii.ac.jp/records/53