{"_buckets": {"deposit": "bb25b04f-94fe-45bd-8c67-7a96861e2e1c"}, "_deposit": {"created_by": 15, "id": "256", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "256"}, "status": "published"}, "_oai": {"id": "oai:tohoku-mpu.repo.nii.ac.jp:00000256", "sets": ["5"]}, "author_link": [], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "51", "bibliographicPageEnd": "141", "bibliographicPageStart": "133", "bibliographic_titles": [{"bibliographic_title": "東北薬科大学研究誌", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Journal of Tohoku Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "米澤, 章彦", "creatorNameLang": "ja"}, {"creatorName": "ヨネザワ, アキヒコ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Yonezawa, Akihiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "善積, 克", "creatorNameLang": "ja"}, {"creatorName": "ヨシズミ, マサル", "creatorNameLang": "ja-Kana"}, {"creatorName": "Yoshizumi, Masaru", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "蛯子, 学", "creatorNameLang": "ja"}, {"creatorName": "エビコ, マナブ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Ebiko, Manabu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "木村, 行雄", "creatorNameLang": "ja"}, {"creatorName": "キムラ, ユキオ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Kimura, Yukio", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "櫻田, 忍", "creatorNameLang": "ja"}, {"creatorName": "サクラダ, シノブ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sakurada, Shinobu", "creatorNameLang": "en"}]}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "Methodological shortcomings present in elicitation of penile erection and ejaculation in anesthetized rats. The present study has demonstrated that intraperitoneal (i.p.) injection of p-chloromethamphetamine (PCMA ; 1-10 mg/kg) and fenfluramine (FEN ; 1-10 mg/kg), the serotonin (5-HT) releasing drugs, elicited dose-dependently both penile erection and ejaculation in anesthetized rats. PCMA (10 mg/kg) and FEN (10 mg/kg) caused an intermittent cluster of genital responses consisting of glans erections and penile cups, which closely resembles the response observed during the ex copula tests in unanesthetized rats. PCMA and FEN also caused frequent ejaculations and the weighing of ejaculates accumulated over 60 min were almost equivalent between both drugs. Pretreatment with a 5-HT synthesis inhibitor p-chlorophenylalanine (150 mg/kg × 3, i.p.) and a selective 5-HT reuptake inhibitor citalopram (1 and 3 mg/kg, i.p.) significantly inhibited the expression of both PCMA- and FEN-induced penile erection and ejaculation, while acute spinal transection (T_\u003c8-9\u003e) did not affect the responses. These results indicate that PCMA- and FEN-induced penile erection and ejaculation in anesthetized rats are mainly elicited by the release of 5-HT which may be limited to the peripheral sites. Furthermore, the sexual responses of male rats can be easily and reliably elicited by the administration of PCMA and FEN, which may be useful for the study of the mechanisms underlying sexual functions.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1149311X", "subitem_source_identifier_type": "NCID"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2004-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004191114.pdf", "filesize": [{"value": "723.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 723200.0, "url": {"label": "KJ00004191114", "objectType": "fulltext", "url": "https://tohoku-mpu.repo.nii.ac.jp/record/256/files/KJ00004191114.pdf"}, "version_id": "f74d70ba-9b37-4999-a25e-5b4ac03829d7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "penile erection", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ejaculation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "serotonin (5-HT) releasing drugs", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "anesthetized rats", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "セロトニン遊離薬p-chloromethamphetamineおよびfenfluramineによる雄ラットの性機能誘発効果", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "セロトニン遊離薬p-chloromethamphetamineおよびfenfluramineによる雄ラットの性機能誘発効果", "subitem_title_language": "ja"}, {"subitem_title": "Penile erection and ejaculation induced by the serotonin releasers in male rats", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "15", "path": ["5"], "permalink_uri": "https://tohoku-mpu.repo.nii.ac.jp/records/256", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2004-12-01"}, "publish_date": "2004-12-01", "publish_status": "0", "recid": "256", "relation": {}, "relation_version_is_last": true, "title": ["セロトニン遊離薬p-chloromethamphetamineおよびfenfluramineによる雄ラットの性機能誘発効果"], "weko_shared_id": -1}
セロトニン遊離薬p-chloromethamphetamineおよびfenfluramineによる雄ラットの性機能誘発効果
https://tohoku-mpu.repo.nii.ac.jp/records/256
https://tohoku-mpu.repo.nii.ac.jp/records/256