| Item type |
紀要論文(ELS) / Departmental Bulletin Paper(1) |
| 公開日 |
2004-12-01 |
| タイトル |
|
|
タイトル |
ラットmonoamine oxidase mRNAの臓器分布と活性値との相関関係 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
Correlation between monoamine oxidase mRNA expression and enzymatic activity in rat tissues |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
monoamine oxidase (MAO) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
tissue distribution |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mRNA expression level |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
enzyme activity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
multiple regression analysis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者名 |
落合, 義徳
駒井, 理恵
伊藤, 邦郎
櫻井, 栄一
田中, 頼久
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Monoamine oxidase A and B (MAO-A and -B, EC 1.4.3.4) are the major enzymes that catalyze the oxidative deamination of neurotransmitters, peripheral vasoactive amines and xenobiotics. MAO-A and -B can be distinguished by difference in substrate preference and inhibitor specificity, tissue and cell distribution, and immunological properties. There are significant discrepancies in the literature concerning the amount of MAO from a number of tissue sources. Using real-time PCR, we measured MAO mRNA expression levels and both amine oxidase activity without the influence of inhibitors. Then we compared tissue amine oxidase activity with the MAO-A and -B mRNA expression level by simple regression analysis. MAO-A mRNA expression level and benzylamine oxidative deamination activity showed good correlation. However, regression analysis of other substrates and mRNA levels showed moderate or no correlation. Further, we recalculated those data using multiple regression analysis. All substrates showed good or moderate correlation. In conclusion, these results indicated that there is a fixed relation of amine oxidase activity in tissues and mRNA expression level. |
|
言語 |
en |
| 書誌情報 |
ja : 東北薬科大学研究誌
en : Journal of Tohoku Pharmaceutical University
号 51,
p. 97-105,
発行日 2004-12
|
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1149311X |
KJ00004191110 (854.7 kB)
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