| Item type |
紀要論文(ELS) / Departmental Bulletin Paper(1) |
| 公開日 |
2006-12-01 |
| タイトル |
|
|
タイトル |
抗原誘発性Th1・Th2サイトカイン産生に対する性ホルモンの影響の性差 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
The effect of sex hormone on antigen-induced Th1/Th2 cytokine production |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
asthma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gender difference |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
sex hormone |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lymphocyte |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Th2 cytokine |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者名 |
今村, 幸恵
久保田, 智子
高梨, 加奈子
森, 聡恵
吉田, 良太
和田, 佳奈
奥山, 香織
高柳, 元明
大野, 勲
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The incidence, severity and prognosis of asthma can be affected by a number of factors, including the patient's age and sex. Clinical observations and epidemiologic studies indicate that the prevalence and severity of asthma is higher among boys than girls, but that the ratio inverts after puberty. The reversal of the male/female prevalence of asthma at puberty strongly suggests a role of sex hormones. However, the mechanisms underlying the gender differences in the prevalence of asthma are not clear. Recently, we suggested that the sex differences were due to those in not only sex hormones but also lymphocyte functions based on findings in a murine model of allergic asthma. Therefore, we investigated the effect of sex hormones on antigen-induced cytokine production by lymphocytes to further investigate these gender differences. Splenocytes from ovalbumin (OVA)-sensitized female mice produced more IL-5, Th2 cytokine, than those from OVA-sensitized male mice, upon simulation with OVA. Progesterone decreased the production of IFN-g, Th1 cytokine, by splenocytes from both sensitized male and female mice. 17β-estradiol had no effect on Th1 and Th2 cytokine production by splenocytes from both mice. However, 5a-dihydrotestosterone decreased the production of Th2 cytokines by splenoytes from sensitized female mice but not these from male mice. Our findings suggest that lymphocytes from males and females have different sensitivities to sex hormones in antigen-induced cytokine production. |
|
言語 |
en |
| 書誌情報 |
ja : 東北薬科大学研究誌
en : Journal of Tohoku Pharmaceutical University
号 53,
p. 77-84,
発行日 2006-12
|
| 収録 NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1149311X |
KJ00004687279 (635.8 kB)
