| Item type |
紀要論文(ELS) / Departmental Bulletin Paper(1) |
| 公開日 |
2005-12-01 |
| タイトル |
|
|
タイトル |
釣藤鉤の主要なインドールアルカロイドhirsuteine及びhirsutineの糞及び尿中代謝物について |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
Fecal and Urinary Metabolites of Hirsuteine and Hirsutine, the Major Indole Alkaloids in Uncaria rhynchophylla, in Rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hirsuteine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hirsutine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
metabolites |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
feces |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
urine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Uncaria rhynchophylla |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者名 |
伴場, 光一
中澤, 孝浩
館岡, 礼奈
大澤, 啓助
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
As a part of our studies on the metabolic fate of hirsuteine (HT) and hirsutine (HS), the indole alkaloids of Uncaria rhynchophylla, fecal and urinary metabolites of HT and HS were analyzed by a HPLC equipped with a photodiode array detector. Feces samples from rats orally administered HT was found to contain a metabolite. Similarly, feces samples from HS were a metabolite. The metabolites of HT and HS in feces were identified as 11-hydroxyhirusuteine and 11-hydroxyhirusutine by direct comparison with authentic samples on HPLC, respectively. The parent compound was detected from only feces samples from HT. Total cumulative fecal excretion during 72h after the oral administration of HT and HS was approximately 7% and 8%, respectively. On the other hand, urinary excretion during 24h after the intravenous administration of HT and HS was approximately 5% and 12%. |
|
言語 |
en |
| 書誌情報 |
ja : 東北薬科大学研究誌
en : Journal of Tohoku Pharmaceutical University
号 52,
p. 65-72,
発行日 2005-12
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| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1149311X |
KJ00004373129 (558.5 kB)
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