| Item type |
紀要論文(ELS) / Departmental Bulletin Paper(1) |
| 公開日 |
2008-12-01 |
| タイトル |
|
|
タイトル |
Menadione 処理した Candida albicans ROS 生産機構の解析 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
Analysis of ROS Production Mechanism in Candida albicans Treated with Menadione |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Candida albicans; ROS; Menadione; NDH51 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者名 |
上野, 将明
小笠原, 綾子
渡部, 俊彦
三上, 健
松本, 達二
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Menadione shows anti Condida activity by promoting ROS production. However, the ROS production mechanism has not been clarifield. Thus, in this study, we studied thr relation between anti Candida activity of menadione and ROS production. Menadione inhibited the growth of C. albicans BWP17 strain, the growth of C. albicans JM02 strain was not inhibited. ROS production in C. albicans BWP17 strain was enhanced by addition of menadione. The ROS production in C. albicans JM02 strain was also enhanced by menadione, however, the amount of ROS was lower than that in menadione untreated C. albicans BWP17 strain. NDH51 is 51-kDa subunit of NADH dehydrogenase complex I, and C. albicans JM02 strain is deficient in NDH51 strain. Rotenone, an NADH dehydrogenase complex I inhibitor, decreased the menadione sensitivity of the C. albicans BWP17 strain, indicating that NDH51 related to the menadione sensitivity of C. albicans. The expression of NDH51 mRNA was increased by menadione in C. albicans BWP17 strain. These results indicated that menadion inhibited the growthe of C. albicans by stimulating the ROS production system though activation of NDH51 in C. albicans. |
|
言語 |
en |
| 書誌情報 |
ja : 東北薬科大学研究誌
en : Journal of Tohoku Pharmaceutical University
号 55,
p. 57-61,
発行日 2008-12
|
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1149311X |
KJ00007222759 (898.8 kB)
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