{"created":"2023-06-20T13:11:05.687022+00:00","id":119,"links":{},"metadata":{"_buckets":{"deposit":"76d99294-f58f-4fb8-a34a-a9605d499753"},"_deposit":{"created_by":15,"id":"119","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"119"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000119","sets":["3:12"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"55","bibliographicPageEnd":"61","bibliographicPageStart":"57","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上野, 将明","creatorNameLang":"ja"},{"creatorName":"ウエノ, ユキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ueno, Yukihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小笠原, 綾子","creatorNameLang":"ja"},{"creatorName":"オガサワラ, アヤコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogasawara, Ayako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"渡部, 俊彦","creatorNameLang":"ja"},{"creatorName":"ワタナベ, トシヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Toshihiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"三上, 健","creatorNameLang":"ja"},{"creatorName":"ミカミ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Mikami, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"松本, 達二","creatorNameLang":"ja"},{"creatorName":"マツモト, タツジ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Tatsuji","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Menadione shows anti Condida activity by promoting ROS production. However, the ROS production mechanism has not been clarifield. Thus, in this study, we studied thr relation between anti Candida activity of menadione and ROS production. Menadione inhibited the growth of C. albicans BWP17 strain, the growth of C. albicans JM02 strain was not inhibited. ROS production in C. albicans BWP17 strain was enhanced by addition of menadione. The ROS production in C. albicans JM02 strain was also enhanced by menadione, however, the amount of ROS was lower than that in menadione untreated C. albicans BWP17 strain. NDH51 is 51-kDa subunit of NADH dehydrogenase complex I, and C. albicans JM02 strain is deficient in NDH51 strain. Rotenone, an NADH dehydrogenase complex I inhibitor, decreased the menadione sensitivity of the C. albicans BWP17 strain, indicating that NDH51 related to the menadione sensitivity of C. albicans. The expression of NDH51 mRNA was increased by menadione in C. albicans BWP17 strain. These results indicated that menadion inhibited the growthe of C. albicans by stimulating the ROS production system though activation of NDH51 in C. albicans.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2008-12-01"}],"displaytype":"detail","filename":"KJ00007222759.pdf","filesize":[{"value":"898.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00007222759","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/119/files/KJ00007222759.pdf"},"version_id":"d617b80e-7d3d-44ba-b8e3-5bea0dea0a63"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Candida albicans; ROS; Menadione; NDH51","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Menadione 処理した Candida albicans ROS 生産機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Menadione 処理した Candida albicans ROS 生産機構の解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of ROS Production Mechanism in Candida albicans Treated with Menadione","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["12"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-12-01"},"publish_date":"2008-12-01","publish_status":"0","recid":"119","relation_version_is_last":true,"title":["Menadione 処理した Candida albicans ROS 生産機構の解析"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:47:39.127020+00:00"}