{"created":"2023-06-20T13:11:04.749609+00:00","id":97,"links":{},"metadata":{"_buckets":{"deposit":"7490aac1-d680-4f9f-9c23-e03754485e85"},"_deposit":{"created_by":15,"id":"97","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"97"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000097","sets":["3:13"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"56","bibliographicPageEnd":"58","bibliographicPageStart":"55","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐々木, 健郎","creatorNameLang":"ja"},{"creatorName":"ササキ, ケンロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Kenroh","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"伊東, 宗一","creatorNameLang":"ja"},{"creatorName":"イトウ, ソウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, So-ichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"今野, 那美","creatorNameLang":"ja"},{"creatorName":"コンノ, トモミ","creatorNameLang":"ja-Kana"},{"creatorName":"Konno, Tomomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉﨑, 文彦","creatorNameLang":"ja"},{"creatorName":"ヨシザキ, フミヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshizaki, Fumihiko","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Saiko-ka-ryukotsu-borei-to (SRBT) is adapted for psychoneurosis,such as autonomic dystonia and sleep disorder. Is has been postulated that reactive oxygen species (ROSs) plays an important role in psychoneurosis arising from oxidative neurogeneration.In this study,effect of SRBT on the formation of hydrogen peroxide generated by rat liver mitochondria oxdase (MAO) was investigated by enzymatic colorimetric assay using 2,2'-Azino-bis(3-ethyl benzthiazoline-6-sulfonic acid) (ABTS) oxidation catalyzed by peroxidase in vitro.SRBT (1mg/ml) had exhibited notable inhibition on the coupling reaction of ABTS radical cation with a hydrogen peroxide formed by peroxidase,suggesting inhibitory effect on monoamine oxdase activity.Comparative determination of the consequence on MAO with the lacking of each crude drug blended in SRBT indicated that Scutellaria root should by the active constituent participated with this activity.In Addition,when the MAO-inhibitory activity was compared with the partition of Sctellaria root decoction,the ethyl acetate-soluble layer had found to be the most effective in comparison with the other layers.Wogonin and baicalein had been revealed the principal components in ethyl acetate-soluble layer of Scutellaria root by TLC.These results have suggested that flavonoids derived from Scutellaria root might be involved in the inhibitory activity of SRBT on rat liver MAO.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-12-01"}],"displaytype":"detail","filename":"KJ00007286519.pdf","filesize":[{"value":"894.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00007286519","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/97/files/KJ00007286519.pdf"},"version_id":"c29a727a-7057-44e3-bc18-e6da4210d069"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Saiko-ka-ryukotsu-borei-to ; monoamine oxidase ; hydrogen peroxidase ; ABTS/peroxidase colorimetric assay ; Scutellaria root ; flavonoids","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット肝ミトコンドリアMonoamine Oxidaseによる過酸化水素産生系に対する柴胡加龍骨牡蠣湯の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット肝ミトコンドリアMonoamine Oxidaseによる過酸化水素産生系に対する柴胡加龍骨牡蠣湯の影響","subitem_title_language":"ja"},{"subitem_title":"Effect of Saiko-ka-ryoukotsu-borei-to on the Formation of Hydrogen Peroxide Generated by Rat Liver Mitochondria-monoamin Oxidase","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["13"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-12-01"},"publish_date":"2009-12-01","publish_status":"0","recid":"97","relation_version_is_last":true,"title":["ラット肝ミトコンドリアMonoamine Oxidaseによる過酸化水素産生系に対する柴胡加龍骨牡蠣湯の影響"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:46:20.790940+00:00"}