@article{oai:tohoku-mpu.repo.nii.ac.jp:00000873,
 author = {本田, 慎太朗 and Honda, Shintaro and 藤盛, 寿一 and Fujimori, Juichi and 中島, 一郎 and Nakashima, Ichiro},
 issue = {69},
 journal = {東北医科薬科大学研究誌, Journal of Tohoku Medical and Pharmaceutical University},
 month = {Dec},
 note = {Background: Although cognitive impairment（CI）is increasingly recognized as a core feature of multiple sclerosis （MS）, the exact mechanisms that underlie CI are poorly understood. However, a recent study suggested that cortical atrophy and cognitive decline accelerate together during the progressive phase of MS. In this study, we aimed to clarify at what stage the progression of CI increases in Japanese patients with MS.
Methods: In this longitudinal retrospective analysis, fifty-five consecutive Japanese MS patients — relapsing-remitting MS（RRMS）（76%）and secondary progressive MS（SPMS）（24%）—were included. We evaluated the information processing speed（IPS）, calculated the raw score and Z score, and investigated how much the values declined from 2021 to 2022. Brain volumes were evaluated with FreeSurfer software.
Results: Patients with SPMS had more severe physical disability, lower IPS, and more prominent brain atrophy than patients with RRMS, but there was no significant difference in the annual change in IPS. However, since three of the 13 SPMS patients transitioned from RRMS to SPMS between 2019 and 2021, we divided SPMS patients into the RRMS-to-SPMS transition group and the SPMS group and repeated the analysis. Compared with the RRMS group and RRMS-to-SPMS transition group, the SPMS group showed a significant increase in its annual IPS decline. The SPMS group had a lower Z score in 2021 than the other two groups, and the score tended to decrease further in 2022. Conclusion: Impairment in IPS begins to progress rapidly 2 years or more after the onset of the SPMS phenotype.},
 pages = {33--39},
 title = {多発性硬化症の高次脳機能障害の進行に関する病期別の比較検討},
 year = {2022},
 yomi = {ホンダ, シンタロウ and フジモリ, ジュイチ and ナカシマ, イチロウ}
}