@article{oai:tohoku-mpu.repo.nii.ac.jp:00000872,
 author = {木村, 諒 and Kimura, Ryo and 藤盛, 寿一 and Fujimori, Juichi and 中島, 一郎 and Nakashima, Ichiro},
 issue = {69},
 journal = {東北医科薬科大学研究誌, Journal of Tohoku Medical and Pharmaceutical University},
 month = {Dec},
 note = {Objective: To create a diagnostic algorithm and evaluate severity using nuclear medical imaging in patients with Parkinsonʼs disease（PD）-related disorders.
Methods: Forty-seven patients with PD, 17 patients with progressive supranuclear palsy（PSP）, and 5 patients with multiple system atrophy（MSA）were studied. By applying a machine learning method to data from meta-iodobenzylguanidine（MIBG）myocardial scintigraphy or dopamine transporter（DAT）scintigraphy, we tried to create a diagnostic algorithm to assist in the differential diagnosis of patients with PD, PSP, and MSA. We also searched for quantitative values in these images that could reflect the severity of PD-related disorders.
Results: The three disease groups were not significantly different in age, gender, disease duration, or severity. Compared to patients with PSP and those with MSA, patients with PD had a significantly reduced heart/mediastinum（H/M）ratio in early and/or delayed images on MIBG myocardial scintigraphy. A differential diagnostic algorithm using MIBG myocardial scintigraphy showed that all patients with an H/M ratio（early image） of less than 2.36 and a washout rate of 31.2 or more had PD. In contrast, all patients with PSP had an H/M ratio （early image）of 2.36 or higher. In building an algorithm for differential diagnosis using DAT scintigraphy, we found that more than half of patients with PSP had a specific binding ratio（SBR）of less than 2.615, and the frequency was higher in PSP than in the other two diseases. The severity of PD-related disorders was not significantly correlated with any other variable except the degree of SBR.
Conclusion: Nuclear medical imaging might be useful in the establishment of a diagnostic algorism and severity assessment of PD-related diseases.},
 pages = {25--32},
 title = {パーキンソン病関連疾患における核医学検査定量値を用いた 診断アルゴリズム作成の試み},
 year = {2022},
 yomi = {キムラ, リョウ and フジモリ, ジュイチ and ナカシマ, イチロウ}
}