@article{oai:tohoku-mpu.repo.nii.ac.jp:00000815, author = {五十嵐, 健人 and Igarashi, Kento and 富田, 和男 and Tomita, Kazuo and 桑原, 義和 and Kuwahara, Yoshikazu and 栗政, 明弘 and Kurimasa, Akihiro and 佐藤, 友昭 and Sato, Tomoaki}, issue = {67}, journal = {東北医科薬科大学研究誌, Journal of Tohoku Medical and Pharmaceutical University}, month = {Dec}, note = {Oxytocin is a neuropeptide that acts not only on peripheral tissues but also on the central nervous system, and plays an important role in social behavior including reproductive behavior and aggressive behavior. In clinical trials, it has been reported that oxytocin has the effect of promoting sociality, such as improving the ability to infer the psychology of others, while it has also been reported to increase jealousy. The social salience hypothesis has been proposed recently to comprehensively understand changes in human behavior under different experimental conditions, although the molecular substance involved in psychological changes is not well understood. mice, rats, and prairie voles have been used to understand the effects of oxytocin, and it has been reported that reproductive behavior improves partner preference and reduces aggression against other individuals of the same sex, which would form experimental basis to verify the effects of oxytocin. In this review, we will outline the reports so far in clinical trials and ethological experiments using oxytocin from the viewpoint of their effects on social behavior along with the results of our recent experiments, and discuss future issues.}, pages = {41--45}, title = {オキシトシンの精神作用と精神疾患治療への応用に向けたアプローチ}, year = {2020}, yomi = {イガラシ, ケント and トミタ, カズオ and クワハラ, ヨシカズ and クリマサ, アキヒロ and サトウ, トモアキ} }