@article{oai:tohoku-mpu.repo.nii.ac.jp:00000814,
 author = {原, 明義 and Hara, Akiyoshi},
 issue = {67},
 journal = {東北医科薬科大学研究誌, Journal of Tohoku Medical and Pharmaceutical University},
 month = {Dec},
 note = {Coffee is a widely consumed beverage around the world. Caffeine, a major component of coffee, acts as a nonselective blocker of adenosine A1 and A2 receptors; blockade of A1 receptors with caffeine accelerates the release of catecholamines from sympathetic nerve endings, and blockade of A2 receptors inhibits the vasodilatory effect of adenosine. These facts lead to a view that caffeine and caffeinated coffee may affect on the cardiovascular system in addition to the stimulating action on the central nervous system. In fact, many previous reports have demonstrated that acute intake of caffeine or coffee increases blood pressure（BP）in humans in Europe and the United States. We also observed that drinking of a cup of coffee increases systolic and diastolic BP in the non-habitual coffee consumers in young normotensive Japanese subjects. In the habitual coffee consumers, however, coffee drinking increased neither systolic nor diastolic BP. According to the studies that targeted the chronic（long-term）effects, repeated intake of caffeine and coffee have no or rather a decreasing effect on BP, probably because of the development of tolerance. In addition, recent epidemiological studies have demonstrated that mild to moderate intake of coffee does not increase the risk of hypertension and cardiovascular events such as coronary heart disease and stroke. The habitual consumption of coffee may benefit on the cardiovascular system, although its mechanism is not fully understood.},
 pages = {33--39},
 title = {コーヒーと循環器疾患　～コーヒーは高血圧のリスク因子か？～},
 year = {2020},
 yomi = {ハラ, アキヨシ}
}