{"created":"2023-06-20T13:11:35.370178+00:00","id":812,"links":{},"metadata":{"_buckets":{"deposit":"c8665ec6-18d7-4c98-b04a-2a3e24b5cb4a"},"_deposit":{"created_by":15,"id":"812","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"812"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000812","sets":["3:82"]},"author_link":[],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"67","bibliographicPageEnd":"23","bibliographicPageStart":"15","bibliographic_titles":[{"bibliographic_title":"東北医科薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Medical and Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mercury is a heavy metal that is widely present in nature. Methylmercury, which is formed from inorganic mercury in the environment, biomagnifies in fishes via the food chain. It is known to cause severe central nervous system(CNS)damage in humans who consume large amounts of such fishes. Recent reports of impaired motor and mental development in children born to women who consumed fish containing high methylmercury levels during pregnancy have raised serious concerns worldwide. However, the mechanisms underlying methylmercuryinduced CNS damage remain largely unknown. In this review, we introduce the toxicokinetics of mercury compounds and known mechanisms of methylmercury toxicity. Furthermore, we discuss the methylmercuryinduced CNS damage as a result of brain inflammation, which has been actively studied in recent years, including our findings.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北医科薬科大学","subitem_publisher_language":"ja"}]},"item_10002_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2432-5724","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"黄, 基旭","creatorNameLang":"ja"},{"creatorName":"ファン, ギウク","creatorNameLang":"ja-Kana"},{"creatorName":"Hwang, Gi-Wook","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-30"}],"displaytype":"detail","filename":"総説2_黄基旭.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"メチル水銀毒性発現機構に関する最近の研究動向","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/812/files/総説2_黄基旭.pdf"},"version_id":"e263c531-84d8-402d-9fc4-97ad4de26141"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"methylmercury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"toxicity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mechanism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"brain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"メチル水銀毒性発現機構に関する最近の研究動向","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"メチル水銀毒性発現機構に関する最近の研究動向","subitem_title_language":"ja"},{"subitem_title":"Recent Research on the Underlying Mechanisms of Methylmercury Toxicity","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["82"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-30"},"publish_date":"2021-04-30","publish_status":"0","recid":"812","relation_version_is_last":true,"title":["メチル水銀毒性発現機構に関する最近の研究動向"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:40:42.022814+00:00"}