{"created":"2023-06-20T13:11:34.027329+00:00","id":784,"links":{},"metadata":{"_buckets":{"deposit":"dd4b7bec-fd0a-458d-bb99-09baefd0923a"},"_deposit":{"created_by":15,"id":"784","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"784"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000784","sets":["3:71"]},"author_link":[],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"66","bibliographicPageEnd":"18","bibliographicPageStart":"11","bibliographic_titles":[{"bibliographic_title":"東北医科薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Medical and Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Antibodies are glycosylated proteins which play a central role in immune system. much attention has been paid for N-glycosylation at asn297 of igg Fc. it has been well established that the Fc N-glycan is essential for expressingproper effector functions such as Fc receptor binding and complement activation. The underlying mechanism how the N-glycan affect Fc receptor binding has been analyzed and discussed from the structural data. This review will focus on the current understanding how Fc N-glycosylation impacts on the structure and function of the Fc. Finally, techniques are introduced to remodel the N-glycan attached to Fc.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北医科薬科大学","subitem_publisher_language":"ja"}]},"item_10002_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2432-5724","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山口, 芳樹","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, ヨシキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamaguchi, Yoshiki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-12"}],"displaytype":"detail","filename":"総説2_山口芳樹.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"免疫グロブリン結合糖鎖の構造−機能相関","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/784/files/総説2_山口芳樹.pdf"},"version_id":"04f19028-775a-490d-9ada-dbfad807b677"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fc receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"N-glycan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunoglobulin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dynamics","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"免疫グロブリン結合糖鎖の構造−機能相関","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"免疫グロブリン結合糖鎖の構造−機能相関","subitem_title_language":"ja"},{"subitem_title":"Structure-Function Relationship of Immunoglobulin Glycan","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["71"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-12"},"publish_date":"2020-06-12","publish_status":"0","recid":"784","relation_version_is_last":true,"title":["免疫グロブリン結合糖鎖の構造−機能相関"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:40:52.344279+00:00"}