@article{oai:tohoku-mpu.repo.nii.ac.jp:00000783,
 author = {渡部, 輝明 and Watabe, Teruaki},
 issue = {66},
 journal = {東北医科薬科大学研究誌, Journal of Tohoku Medical and Pharmaceutical University},
 month = {Dec},
 note = {An epidemiologically successful subtypes of persistently circulating viruses such as influenza H3N2 subtype are those that can evade host s herd immunity by continuously changing their antigenicity. During the antigenic drift,the substitutions occurred on the genome are subject to selection. On the proteins that determine the antigenicity of the virus, the selection pressure is distributed, making the virus adapt to the change of host s herd immunity. On the other hand, the herd immunity reflects the change of antigenicity of the virus. To properly analyze the fate of a viral subtype that performs such antigenic drift, we introduced a new measure, meta-R0, that describes whether  a subtype can persist in the face of the herd immunity mounted against each antigenic strain. The meta-R0 is defined as the expected number of the new antigenicity strains produced during the epidemic outbreak of the primary strain that will cause the next epidemic outbreak. This approach enables us to understand two contrasting epidemiological characteristics of the influenza H3N2 subtype: the persistent circulation in the human population and the slim phylogenic tree for their antigenic evolution. We revealed that by simply restricting the co-infection of viruses to the host, a viral subtype can securely persist by alternating its antigenic properties with keeping a slender phylogenetic tree shape. The coexistence of these two characteristics is protected due to the negative feedback between the within-year viral diversity and the meta-R0. Here we review epidemiological characteristics of the antigenic evolution of influenza H3N2 subtype.},
 pages = {1--9},
 title = {A 型インフルエンザウイルスの抗原進化〜低次元抗原多様性と長期流行持続〜},
 year = {2019},
 yomi = {ワタベ, テルアキ}
}