{"created":"2023-06-20T13:11:33.470981+00:00","id":771,"links":{},"metadata":{"_buckets":{"deposit":"b94528fa-d08a-405f-8f5a-66a85f67666e"},"_deposit":{"created_by":15,"id":"771","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"771"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000771","sets":["3:70"]},"author_link":[],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"65","bibliographicPageEnd":"61","bibliographicPageStart":"55","bibliographic_titles":[{"bibliographic_title":"東北医科薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Medical and Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A male patient in his 70s with hepatocellular carcinoma（HCC）was treated using sorafenib, but treatment was discontinued due to side effects, including renal dysfunction, proteinuria and hand-foot syndrome. he was then hospitalized to undergo HCC treatment using lenvatinib. as lenvatinib caused renal impairment and proteinuria, it was difficult to manage the side effects and set the dosage. Pathological examination of the kidney biopsy revealed that the thrombotic microangiopathy（TMA）observed in the specimen was related to renal dysfunction. Currently, there are fewer drugs for HCC management than for other types of cancer; only 3 anti-vascular endothelial growth factor receptor（VEGFR）drugs, sorafenib, regorafenib and lenvatinib, are available for HCC therapy. Therefore, these drugs should be used carefully for as long as possible. To our knowledge, this is the first report of TMA during lenvatinib therapy for HCC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北医科薬科大学","subitem_publisher_language":"ja"}]},"item_10002_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2432-5724","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 将典","creatorNameLang":"ja"},{"creatorName":"タカハシ, マサノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Masanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"薄井, 健介","creatorNameLang":"ja"},{"creatorName":"ウスイ, ケンスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Usui, Kensuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岡田, 浩司","creatorNameLang":"ja"},{"creatorName":"オカダ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Okada, Kouji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小暮, 高之","creatorNameLang":"ja"},{"creatorName":"コグレ, タカユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kogure, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 賢一","creatorNameLang":"ja"},{"creatorName":"サトウ, ケンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Satoh, Kennichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中村, 仁","creatorNameLang":"ja"},{"creatorName":"ナカムラ, ヒトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Hitoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"村井, ユリ子","creatorNameLang":"ja"},{"creatorName":"ムライ, ユリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Murai, Yuriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"渡辺, 善照","creatorNameLang":"ja"},{"creatorName":"ワタナベ, ヨシテル","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Yoshiteru","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-15"}],"displaytype":"detail","filename":"症例1_高橋将典.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"レンバチニブ治療開始後に血栓性微小血管障害をきたした肝細胞癌の1例","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/771/files/症例1_高橋将典.pdf"},"version_id":"3b839922-703b-4746-8464-bf6e7cd92b49"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lenvatinib","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thrombotic microangiopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-VEGFR action","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"レンバチニブ治療開始後に血栓性微小血管障害をきたした肝細胞癌の1例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"レンバチニブ治療開始後に血栓性微小血管障害をきたした肝細胞癌の1例","subitem_title_language":"ja"},{"subitem_title":"A Case of Thrombotic Microangiopathy Associated with Lenvatinib for Hepatocellular Carcinoma","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["70"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-15"},"publish_date":"2020-01-15","publish_status":"0","recid":"771","relation_version_is_last":true,"title":["レンバチニブ治療開始後に血栓性微小血管障害をきたした肝細胞癌の1例"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:41:31.012444+00:00"}