{"created":"2023-06-20T13:11:31.433219+00:00","id":732,"links":{},"metadata":{"_buckets":{"deposit":"207ea9fd-09af-4dde-935d-8b1cf6772a48"},"_deposit":{"created_by":15,"id":"732","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"732"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000732","sets":["3:69"]},"author_link":[],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"64","bibliographicPageEnd":"48","bibliographicPageStart":"39","bibliographic_titles":[{"bibliographic_title":"東北医科薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Medical and Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Radiotherapy（RT）is one of the major modalities for the treatment of human cancers and has been established as an excellent local treatment for malignant tumors. Conventional fractionated RT consists of 2-Gy X-rays, fractionated once a day, 5 days a week for 5-7 weeks in total 60 Gy. The efficacy of RT depends on the existence of radioresistant cells, which remains one of the most critical obstacles in RT and radio-chemotherapy. To improve the efficacy of RT understanding the characteristics of radioresistant cells is one of the important subjects in radiation biology. However, the concordant mechanisms of cellular radioresistance have not been clarified yet, presumably because radioresistance has been studied among cells with different genetic backgrounds, that is, cells from different origins. Recently, a system to compare between radioresistant and sensitive cells with the isogenic background was established.  In this review, some aspects of cellular radioresistance mainly focusing on clinically relevant radioresistant（CRR）cell lines that can continue to proliferate even under exposure to 2-Gy X-rays, once a day, for more than 30 days are described.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北医科薬科大学","subitem_publisher_language":"ja"}]},"item_10002_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2432-5724","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"桑原, 義和","creatorNameLang":"ja"},{"creatorName":"クワハラ, ヨシカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Kuwahara, Yoshikazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"富田, 和男","creatorNameLang":"ja"},{"creatorName":"トミタ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Tomita, Kazuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"漆原, 佑介","creatorNameLang":"ja"},{"creatorName":"ウルシハラ, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Urushihara, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"齋藤, 陽平","creatorNameLang":"ja"},{"creatorName":"サイトウ, ヨウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Saito, Yohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 友昭","creatorNameLang":"ja"},{"creatorName":"サトウ, トモアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Tomoaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"栗政, 明弘","creatorNameLang":"ja"},{"creatorName":"クリマサ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kurimasa, Akihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"福本, 学","creatorNameLang":"ja"},{"creatorName":"フクモト, マナブ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukumoto, Manabu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-12-06"}],"displaytype":"detail","filename":"総説4_桑原義和.pdf","filesize":[{"value":"6.6 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"2 Gy/日のX 線分割照射に抵抗性を示すがん細胞の樹立と解析","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/732/files/総説4_桑原義和.pdf"},"version_id":"97ddf661-1220-46ab-adce-79761f1ce964"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cancer radiotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"clinically relevant radioresistant（CRR）cell line","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fractionated radiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radioresistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2 Gy/日のX 線分割照射に抵抗性を示すがん細胞の樹立と解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2 Gy/日のX 線分割照射に抵抗性を示すがん細胞の樹立と解析","subitem_title_language":"ja"},{"subitem_title":"Radioresistant Cell Lines which Continue to Proliferate under Exposure to 2 Gy/day of X-Rays","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["69"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-12-06"},"publish_date":"2018-12-06","publish_status":"0","recid":"732","relation_version_is_last":true,"title":["2 Gy/日のX 線分割照射に抵抗性を示すがん細胞の樹立と解析"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:41:33.133740+00:00"}