{"created":"2023-06-20T13:11:31.304728+00:00","id":729,"links":{},"metadata":{"_buckets":{"deposit":"c065cc14-60a7-4b4a-8a11-41ebe8b2efc1"},"_deposit":{"created_by":15,"id":"729","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"729"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000729","sets":["3:69"]},"author_link":[],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"64","bibliographicPageEnd":"16","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"東北医科薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Medical and Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the process of new antibiotic developments, many drug candidates from in vitro assay systems often have no therapeutic effects in in vivo animal models using mammal.\nTo overcome this problem, we established an in vivomimic infection assay using silkworm larvae as a host animal, and started to apply this assay to the primary screening for new antibiotics of microbial origin.\nComparing with an in vitro assay using paper disk method, the hit rate of candidate culture broths showing a therapeutic effect in silkworm infection assay markedly decreased, but isolated compounds have included some clinical drugs and their related compounds.\nFurthermore, we discovered new anti-MRSa antibiotics, designated nosokomycins A to D, from the culture broth of Streptomyces cyslabdanicas K04-0144, and demonstrated that nosokomycin A also showed a good therapeutic effect in an in vivo mouse infection assay as well as silkworm infection assay.\nThus, we predicted that candidate compounds discovered by silkworm infection assay would have higher potential as antibiotic leads.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北医科薬科大学","subitem_publisher_language":"ja"}]},"item_10002_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2432-5724","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内田, 龍児","creatorNameLang":"ja"},{"creatorName":"ウチダ, リュウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Uchida, Ryuji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-12-06"}],"displaytype":"detail","filename":"総説1_内田龍児.pdf","filesize":[{"value":"6.6 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"微生物資源からの新規抗生物質のスクリーニング","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/729/files/総説1_内田龍児.pdf"},"version_id":"37e145bd-fef9-46e2-9ea8-8056cd3e7b35"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"silkworm infection assay","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antibiotic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microbial origin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"therapeutic effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"in vivo-mimic","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"微生物資源からの新規抗生物質のスクリーニング－簡易的なin vivo様評価系: カイコ感染症モデルを利用して－","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"微生物資源からの新規抗生物質のスクリーニング－簡易的なin vivo様評価系: カイコ感染症モデルを利用して－","subitem_title_language":"ja"},{"subitem_title":"Drug Screening for New Antibiotics of Microbial Origin : in an in vivo -Mimic Infection Assay Using Silkworm Larvae","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"15","path":["69"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-12-06"},"publish_date":"2018-12-06","publish_status":"0","recid":"729","relation_version_is_last":true,"title":["微生物資源からの新規抗生物質のスクリーニング－簡易的なin vivo様評価系: カイコ感染症モデルを利用して－"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:41:34.770386+00:00"}