@article{oai:tohoku-mpu.repo.nii.ac.jp:00000051, author = {小笠原, 綾子 and Ogasawara, Ayako and 渡部, 俊彦 and Watanabe, Toshihiko and 三上, 健 and Mikami, Takeshi and 松本, 達二 and Matsumoto, Tatsuji}, issue = {50}, journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University}, month = {Dec}, note = {Candida albicans is a dimorphic fungus and generally grows in hyphal form in RPMI1640 medium. However, addition of N-acetylneuraminic acid inhibited the hyphal growth. The expression of CGR1 mRNA in C. albicans was inhibited by addition of N-acetylneuraminic acid. Diltiazem, a calcium channel blocker, inhibited the yeast to hyphal transformation in C. albicans as well as addition of N-acetylneuraminic acid. These results indicated that inhibition of hyphal growth of C. albicans by N-acetylneuraminic acid was mediated by interruption of CGR1 mRNA expression.}, pages = {161--165}, title = {N-アセチルノイラミン酸によるCandida albicans形態変化の制御について}, year = {2003}, yomi = {オガサワラ, アヤコ and ワタナベ, トシヒコ and ミカミ, タケシ and マツモト, タツジ} }