{"created":"2023-06-20T13:11:11.630303+00:00","id":308,"links":{},"metadata":{"_buckets":{"deposit":"56d8ce54-0d6c-49d7-b861-6baf41fb750e"},"_deposit":{"created_by":15,"id":"308","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"308"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000308","sets":["3:27"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"58","bibliographicPageEnd":"40","bibliographicPageStart":"35","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 佳奈","creatorNameLang":"ja"},{"creatorName":"コバヤシ, カナ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Kana","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"村上, 知之","creatorNameLang":"ja"},{"creatorName":"ムラカミ, トモユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Murakami, Tomoyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉田, 崇志","creatorNameLang":"ja"},{"creatorName":"ヨシダ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小田, 彰史","creatorNameLang":"ja"},{"creatorName":"オダ, アキフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Oda, Akifumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"高橋, 央宜","creatorNameLang":"ja"},{"creatorName":"タカハシ, オウギ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Ohgi","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"recently, D-amino acids have been found to exist in the human body both as free amino acids and as residues in proteins. The free D-Asp is degraded by d-aspartate oxidase(DDO). DDO with cofactor FAD catalyzes the oxidative deamination of D-Asp and oxaloacetic acid is generated. On the other hand, it is reported that DDO with cofactor FADH2 can also form a complex with D-Asp. in this study, computational docking between D-Asp and DDO was carried out with FAD or FADH2 as the cofactor. The results of docking studies indicate that D-Asp can be recognized both by DDO with FAD and DDO with FADH2, and the difference in binding affinity between the oxidative and reductive states is caused by difference of hydrogen bonding patterns.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2011-12-01"}],"displaytype":"detail","filename":"KJ00008219239.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00008219239","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/308/files/KJ00008219239.pdf"},"version_id":"59b7fd07-4e28-4960-a342-96e56a56b037"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"D-Asp","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"D-aspartate oxidase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FAD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FADH2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"computational docking","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"FADおよびFADH2存在下におけるD-アスパラギン酸酸化酵素とD-アスパラギン酸のドッキングシュミレーション","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"FADおよびFADH2存在下におけるD-アスパラギン酸酸化酵素とD-アスパラギン酸のドッキングシュミレーション","subitem_title_language":"ja"},{"subitem_title":"Prediction of Complex Structures between D-Aspartic acid and D-Aspartate Oxidase with Cofactor FAD or FADH2.","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["27"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-12-01"},"publish_date":"2011-12-01","publish_status":"0","recid":"308","relation_version_is_last":true,"title":["FADおよびFADH2存在下におけるD-アスパラギン酸酸化酵素とD-アスパラギン酸のドッキングシュミレーション"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:45:28.880664+00:00"}