{"created":"2023-06-20T13:11:10.348711+00:00","id":240,"links":{},"metadata":{"_buckets":{"deposit":"cece9664-80a1-4f39-9eba-f330c8473407"},"_deposit":{"created_by":15,"id":"240","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"240"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000240","sets":["3:5"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"51","bibliographicPageEnd":"29","bibliographicPageStart":"23","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 恵子","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ケイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Keiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"伴田, 和香子","creatorNameLang":"ja"},{"creatorName":"ハンダ, ワカコ","creatorNameLang":"ja-Kana"},{"creatorName":"Hannda, Wakako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"長岡, 正男","creatorNameLang":"ja"},{"creatorName":"ナガオカ, マサオ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagaoka, Masao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"沼澤, 光輝","creatorNameLang":"ja"},{"creatorName":"ヌマザワ, ミツテル","creatorNameLang":"ja-Kana"},{"creatorName":"Numazawa, Mituteru","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Aromatase is a cytochrome P-450 enzyme responsible for the conversion of androgens to estrogens. 2,2-Dimethylandrostenedione (5) is one of the powerful inhibitors of the enzyme. To explore a metabolic switching in the aromatase-catalyzed biotransformation of the 2,2-dimethyl steroid 5, possible switching metabolites, the 6β-hydroxy and 6-ene derivatives 9 and 14, as well as 2α-methyl-6β-ol 12 were synthesized and their inhibitory activities of aromatase in human placental microsomes were determined. All of the steroids synthesized were good competitive inhibitors of the enzyme with apparent Ki values ranging from 23 to 110 nM.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2004-12-01"}],"displaytype":"detail","filename":"KJ00004191098.pdf","filesize":[{"value":"517.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00004191098","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/240/files/KJ00004191098.pdf"},"version_id":"bd52e045-58d4-48df-9be8-424e10d81a75"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aromatase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Metabolic switching","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"2,2-Dimethylandrostenedione","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"6β-Hydroxy steroid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Synthesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aromatase inhibition","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2,2-Dimethylanodrostenedioneのアロマターゼ反応におけるメタボリックスイッチングに関する研究 : 予測代謝物の合成とアロマターゼ阻害活性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2,2-Dimethylanodrostenedioneのアロマターゼ反応におけるメタボリックスイッチングに関する研究 : 予測代謝物の合成とアロマターゼ阻害活性","subitem_title_language":"ja"},{"subitem_title":"Study of Aromatase-Catalyzed Metabolic Switching of 2,2-Dimethylandrostenedione : Synthesis of Possible Metabolites and Their Inhibitory Activities of Aromatase","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["5"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2004-12-01"},"publish_date":"2004-12-01","publish_status":"0","recid":"240","relation_version_is_last":true,"title":["2,2-Dimethylanodrostenedioneのアロマターゼ反応におけるメタボリックスイッチングに関する研究 : 予測代謝物の合成とアロマターゼ阻害活性"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:54:30.156554+00:00"}