@article{oai:tohoku-mpu.repo.nii.ac.jp:00000240,
 author = {山田, 恵子 and Yamada, Keiko and 伴田, 和香子 and Hannda, Wakako and 長岡, 正男 and Nagaoka, Masao and 沼澤, 光輝 and Numazawa, Mituteru},
 issue = {51},
 journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University},
 month = {Dec},
 note = {Aromatase is a cytochrome P-450 enzyme responsible for the conversion of androgens to estrogens. 2,2-Dimethylandrostenedione (5) is one of the powerful inhibitors of the enzyme. To explore a metabolic switching in the aromatase-catalyzed biotransformation of the 2,2-dimethyl steroid 5, possible switching metabolites, the 6β-hydroxy and 6-ene derivatives 9 and 14, as well as 2α-methyl-6β-ol 12 were synthesized and their inhibitory activities of aromatase in human placental microsomes were determined. All of the steroids synthesized were good competitive inhibitors of the enzyme with apparent Ki values ranging from 23 to 110 nM.},
 pages = {23--29},
 title = {2,2-Dimethylanodrostenedioneのアロマターゼ反応におけるメタボリックスイッチングに関する研究 : 予測代謝物の合成とアロマターゼ阻害活性},
 year = {2004},
 yomi = {ヤマダ, ケイコ and ハンダ, ワカコ and ナガオカ, マサオ and ヌマザワ, ミツテル}
}