@article{oai:tohoku-mpu.repo.nii.ac.jp:00000224,
 author = {菅原, 実香 and Sugawara, Mika and 比内, 雄大 and Hinai, Yudai and 平塚, 真弘 and Hiratsuka, Masahiro and 佐々木, 崇光 and Sasaki, Takamitsu and 金野, 由美子 and Konno, Yumiko and 水柿, 道直 and Mizugaki, Michinao},
 issue = {52},
 journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University},
 month = {Dec},
 note = {The cytochrome P450 enzymes (GYP) play important roles in the metabolism of many therapeutic agents and environmental compounds. Differences in the activities of these enzymes are thought to be responsible for individual variability in drug response and/or toxicity. Among the GYP enzymes, the isoform CYP4B1 is of particular interest and involved in the metabolism of several protoxins such as 2-aminoanthracene and 2-aminofluorene, all of which are bladder carcinogens. The present study compared the relative expression pattern of CYP4B1 in cDNA panels of human tissues. We developed an assay for CYP4B1 mRNA by performing real-time RT-PCR. Using this method, CYP4B1 mRNA levels were analyzed in human tissues. CYP4B1 mRNA was selectively expressed in lung, bladder, and prostate. These findings suggest that a high expression of CYP4B1 increases the risk of tumor by activation of carcinogenic compounds.},
 pages = {125--133},
 title = {ヒトCYP4B1 mRNA発現の臓器差},
 year = {2005},
 yomi = {スガワラ, ミカ and ヒナイ, ユウダイ and ヒラツカ, マサヒロ and ササキ, タカミツ and コンノ, ユミコ and ミズガキ, ミチナオ}
}