{"created":"2023-06-20T13:11:09.465382+00:00","id":222,"links":{},"metadata":{"_buckets":{"deposit":"abc5f0aa-828e-4d67-b781-20e793169268"},"_deposit":{"created_by":15,"id":"222","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"222"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000222","sets":["3:6"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"52","bibliographicPageEnd":"110","bibliographicPageStart":"105","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"溝口, 広一","creatorNameLang":"ja"},{"creatorName":"ミゾグチ, ヒロカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Mizoguchi, Hirokazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"成田, 年","creatorNameLang":"ja"},{"creatorName":"ナリタ, ミノル","creatorNameLang":"ja-Kana"},{"creatorName":"Narita, Minoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"澤井, 敏樹","creatorNameLang":"ja"},{"creatorName":"サワイ, トシキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sawai, Toshiki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"渡辺, 千寿子","creatorNameLang":"ja"},{"creatorName":"ワタナベ, チズコ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Chizuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"長瀬, 博","creatorNameLang":"ja"},{"creatorName":"ナガセ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagase, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"櫻田, 忍","creatorNameLang":"ja"},{"creatorName":"サクラダ, シノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakurada, Shinobu","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"The involvement of endogenous opioid peptides and opioid receptors in supraspinal site on the antinociception induced by cold water swimming was determined using the mouse tail-flick test. The mice forced to swim in cold water for 3 min, showed the marked antinociception. The antinociception induced by cold water swimming was significantly attenuated by intracerebroventricularly (i.c.v.) pretreatment with antiserum against β-endorphin, but not against dynorphin A or [Leu^5] enkephalin. On the other hand, the antinociception was not affected by i.c.v. pretreatment with μ-opioid receptor antagonists β-funaltrexamine and D-Phe-cyclo-(Cys-Tyr-D-Trp-Orn-Thr-Pen)-Thr-NH_2, δ-opioid receptor antagonists naltrindole, 7-benzylidene naltrexone and naltriben, or κ-opioid receptor antagonist nor-binaltorphimine. The present results suggest that the antinociception induced by cold water swimming may be mainly mediated through the release of β-endorphin in the supraspinal site, which act on β-endorphin-sensitive non-μ-, non-δ-, and non-κ-opioid receptor, so called putative ε-opioid receptor.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2005-12-01"}],"displaytype":"detail","filename":"KJ00004373134.pdf","filesize":[{"value":"525.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00004373134","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/222/files/KJ00004373134.pdf"},"version_id":"d29b15ca-b7b6-4b60-8960-a6356d6c2a2b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antinociception","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cold water swimming","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"environmental stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"supraspinal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-endorphin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ε-opioid receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"冷水強制水泳誘発抗侵害作用の発現における脳内β-endorphinならびにεオピオイド受容体の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"冷水強制水泳誘発抗侵害作用の発現における脳内β-endorphinならびにεオピオイド受容体の関与","subitem_title_language":"ja"},{"subitem_title":"Involvement of endogenous β-endorphin and ε-opioid receptors in supraspinal site on the cold water swimming-induced antinociception in mice","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["6"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2005-12-01"},"publish_date":"2005-12-01","publish_status":"0","recid":"222","relation_version_is_last":true,"title":["冷水強制水泳誘発抗侵害作用の発現における脳内β-endorphinならびにεオピオイド受容体の関与"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:50:56.821868+00:00"}