{"created":"2023-06-20T13:11:01.188631+00:00","id":22,"links":{},"metadata":{"_buckets":{"deposit":"ca6703a0-f7a3-491f-95bd-cb1e29c70972"},"_deposit":{"created_by":15,"id":"22","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"22"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000022","sets":["3:16"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"59","bibliographicPageEnd":"67","bibliographicPageStart":"59","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡邉, 一弘","creatorNameLang":"ja"},{"creatorName":"ワタナベ, カズヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Kazuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"高橋, 昌仁","creatorNameLang":"ja"},{"creatorName":"タカハシ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"川越, 悦子","creatorNameLang":"ja"},{"creatorName":"カワゴエ, エツコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawagoe, Etsuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"加藤, 正","creatorNameLang":"ja"},{"creatorName":"カトウ, タダシ","creatorNameLang":"ja-Kana"},{"creatorName":"Katoh, Tadashi","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"The synthesis of the key intermedicate of dehydroxymethylepoxyquinomicin (DHMEQ),a potent and specific NF-kB inhibitor,was achieved. The method involved the following crucial steps:i) direct construction of quinone functionality by degradative oxidation using hypervalent iodine (III) reagents such as (diacetoxyiodo) benzene (PIDA) and [bis(trifluoroacetoxy)iodo]beneze (PIFA);ii) regioselective epoxidation of quinone having a carbamoyl group; and iii) regio- and stereoselective reduction of an epoxyquinone moiety. In addition,a novel DHMEQ analog was synthesized by applying this approach.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2012-12-01"}],"displaytype":"detail","filename":"KJ00008564899.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00008564899","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/22/files/KJ00008564899.pdf"},"version_id":"1d791921-629b-4e74-ab85-7033bf037169"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dehydroxymethylepoxyquinomicin (DHMEQ)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NF-kB inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"degradative oxidation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypervalent iodine (III) reagent","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epoxydation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"NF-kB阻害剤デヒドロキシメチルエポキシキノマイシン(DHMEQ)の鍵中間体および新規類縁体の合成","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NF-kB阻害剤デヒドロキシメチルエポキシキノマイシン(DHMEQ)の鍵中間体および新規類縁体の合成","subitem_title_language":"ja"},{"subitem_title":"Synthesis of the Key Intermediate of NF-kB Inhibitor Dehydroxvmethylepoxyquinomicin (DHMEQ) and Novel DHMEQ Analog","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["16"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-12-01"},"publish_date":"2012-12-01","publish_status":"0","recid":"22","relation_version_is_last":true,"title":["NF-kB阻害剤デヒドロキシメチルエポキシキノマイシン(DHMEQ)の鍵中間体および新規類縁体の合成"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:45:14.777114+00:00"}