@article{oai:tohoku-mpu.repo.nii.ac.jp:00000022,
 author = {渡邉, 一弘 and Watanabe, Kazuhiro and 高橋, 昌仁 and Takahashi, Masato and 川越, 悦子 and Kawagoe, Etsuko and 加藤, 正 and Katoh, Tadashi},
 issue = {59},
 journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University},
 month = {Dec},
 note = {The synthesis of the key intermedicate of dehydroxymethylepoxyquinomicin (DHMEQ),a potent and specific NF-kB inhibitor,was achieved. The method involved the following crucial steps:i) direct construction of quinone functionality by degradative oxidation using hypervalent iodine (III) reagents such as (diacetoxyiodo) benzene (PIDA) and [bis(trifluoroacetoxy)iodo]beneze (PIFA);ii) regioselective epoxidation of quinone having a carbamoyl group; and iii) regio- and stereoselective reduction of an epoxyquinone moiety. In addition,a novel DHMEQ analog was synthesized by applying this approach.},
 pages = {59--67},
 title = {NF-kB阻害剤デヒドロキシメチルエポキシキノマイシン(DHMEQ)の鍵中間体および新規類縁体の合成},
 year = {2012},
 yomi = {ワタナベ, カズヒロ and タカハシ, マサト and カワゴエ, エツコ and カトウ, タダシ}
}