@article{oai:tohoku-mpu.repo.nii.ac.jp:00000216,
 author = {佐々木, 健郎 and Sasaki, Kenroh and 佐藤, 久美子 and Sato, Kumiko and 新井, 栄吉 and Arai, Eikichi and 吉崎, 文彦 and Yoshizaki, Fumihiko},
 issue = {52},
 journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University},
 month = {Dec},
 note = {Rosmarinic acid is an ester of caffeic acid and 3, 4-dihydroxyphenyllactic acid, being found to have a multitude of biological activities such as anti-inflammation, antimutagen and antioxidant. In order to establish the relationship between antioxidants and matrix metalloproteinase (MMP) -inhibitory activity, rosmarinic acid and caffeic acid were evaluated for their potential in 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and blocking of MMP activity. Gelatinase activity was measured using the gelatin degradation and/or gelatin-zymography assay. From comparison of the different levels of DPPH radical scavenging activity, it was deduced that a crucial role in inhibition for MMP activity might play by an antioxidant activity. This comparative study is proposed as a basis for designing the enhanced antiproteolytic activities, and no or reduced side effects for use in hindering inflammation, cancer invasion or metastasis and angiogenesis in lung.},
 pages = {57--63},
 title = {ロズマリン酸の抗酸化作用とラット肺組織マトリックスメタロプロチアーゼ阻害作用について},
 year = {2005},
 yomi = {ササキ, ケンロウ and サトウ, クミコ and アライ, エイキチ and ヨシザキ, フミヒコ}
}