@article{oai:tohoku-mpu.repo.nii.ac.jp:00000198, author = {安藤, 隆一郎 and Ando, Ryuichiro and 渡辺, 千寿子 and Watanabe, Chizuko and 小島, 修樹 and Ojima, Syuki}, issue = {53}, journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University}, month = {Dec}, note = {We investigated the dynamics of cardiovascular system in order to search for the characteristic of vascular pain model using power spectrum analysis. The animals were anesthetized with urethane (1.3g/kg, i.p.) and arterial cannula was inserted into a bifurcation of femoral artery. The recording of heartbeats was carried out by chest bipolar lead. Systolic blood pressure went through a transducer from femoral artery and measured it invasively. In the power spectrum density (PSD) of R-R intervals, it was almost the same as that of un-stimulating state at very low frequency (VLF, <0.08Hz) and low frequency (LF, 0.08-0.3Hz) and high frequency (HF, 0.3-4.0Hz). However, the arterial capsaicin (CAP, 0.2μg) evoked the increment of total PSD values, particularly at LF and VLF, were markedly different from those of pinching. Furthermore, the increase of PSD by CAP was inhibited by morphine (5mg/kg, s.c.). These results indicate that the useful possibility to observation of the autonomic nervous system dynamics induced by vascular pain as a characteristic of this model.}, pages = {117--124}, title = {ラット血管痛モデルにおける循環器パラメーター変動のパワースペクトル解析}, year = {2006}, yomi = {アンドウ, リュウイチロウ and ワタナベ, チズコ and オジマ, シュウキ} }