{"created":"2023-06-20T13:11:08.066619+00:00","id":197,"links":{},"metadata":{"_buckets":{"deposit":"5d4921ac-16ec-407f-9186-5afa478bd634"},"_deposit":{"created_by":15,"id":"197","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"197"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000197","sets":["3:9"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"53","bibliographicPageEnd":"116","bibliographicPageStart":"109","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上井, 幸司","creatorNameLang":"ja"},{"creatorName":"ウワイ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Uwai, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山田, 梨沙","creatorNameLang":"ja"},{"creatorName":"ヤマダ, リサ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Risa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"丘, 龍祥","creatorNameLang":"ja"},{"creatorName":"オカ, リュウショウ","creatorNameLang":"ja-Kana"},{"creatorName":"Oka, Ryusho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"仲川, 義人","creatorNameLang":"ja"},{"creatorName":"ナカガワ, ヨシト","creatorNameLang":"ja-Kana"},{"creatorName":"Nakagawa, Yoshito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"竹下, 光弘","creatorNameLang":"ja"},{"creatorName":"タケシタ, ミツヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeshita, Mitsuhiro","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"There have been very limited reports on the effects of fresh fruit juices on human and rat CYP3A activity. Therefore, the inhibitory effects of readily available fresh fruit juices on midazolam 1'-hydroxylase activity, a marker of CYP3A, were evaluated in pooled human and rat liver microsomes. The fruit investigated in this study were peach, grapefruit, grape, lemon, and pineapple for human and rat CYP3A activity. Grapefruit was used for as positive control. The inhibition depended on the amount of a fruit juice added to the incubation mixture. The inhibitory potential on human CYP3A was in the order : pineapple > lemon > grapefruit > grape > peach, and on rat CYP3A was in the order : lemon > pineapple > grapefruit > grape > peach. Those results suggest that, like grapefruit juice, commercial fruit such as pineapple, and lemon also have the potential to inhibit CYP3A-catalyzed midazolam 1'-hydroxylation. On the other hand, peach juice does not show any effect on CYP3A-catalyzed midazolam 1'-hydroxylation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2006-12-01"}],"displaytype":"detail","filename":"KJ00004687283.pdf","filesize":[{"value":"556.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00004687283","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/197/files/KJ00004687283.pdf"},"version_id":"c56895c7-d640-410d-9729-4023f651e14e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cytochrome P450","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fresh fruit juice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CYP3A inhibition","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"果物ジュースによるヒトおよびラットCYP3A活性の阻害効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"果物ジュースによるヒトおよびラットCYP3A活性の阻害効果","subitem_title_language":"ja"},{"subitem_title":"Inhibitory effects of various fruit juices on human and rat CYP3A activity","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-12-01"},"publish_date":"2006-12-01","publish_status":"0","recid":"197","relation_version_is_last":true,"title":["果物ジュースによるヒトおよびラットCYP3A活性の阻害効果"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:50:55.339244+00:00"}