@article{oai:tohoku-mpu.repo.nii.ac.jp:00000197,
 author = {上井, 幸司 and Uwai, Koji and 山田, 梨沙 and Yamada, Risa and 丘, 龍祥 and Oka, Ryusho and 仲川, 義人 and Nakagawa, Yoshito and 竹下, 光弘 and Takeshita, Mitsuhiro},
 issue = {53},
 journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University},
 month = {Dec},
 note = {There have been very limited reports on the effects of fresh fruit juices on human and rat CYP3A activity. Therefore, the inhibitory effects of readily available fresh fruit juices on midazolam 1'-hydroxylase activity, a marker of CYP3A, were evaluated in pooled human and rat liver microsomes. The fruit investigated in this study were peach, grapefruit, grape, lemon, and pineapple for human and rat CYP3A activity. Grapefruit was used for as positive control. The inhibition depended on the amount of a fruit juice added to the incubation mixture. The inhibitory potential on human CYP3A was in the order : pineapple > lemon > grapefruit > grape > peach, and on rat CYP3A was in the order : lemon > pineapple > grapefruit > grape > peach. Those results suggest that, like grapefruit juice, commercial fruit such as pineapple, and lemon also have the potential to inhibit CYP3A-catalyzed midazolam 1'-hydroxylation. On the other hand, peach juice does not show any effect on CYP3A-catalyzed midazolam 1'-hydroxylation.},
 pages = {109--116},
 title = {果物ジュースによるヒトおよびラットCYP3A活性の阻害効果},
 year = {2006},
 yomi = {ウワイ, コウジ and ヤマダ, リサ and オカ, リュウショウ and ナカガワ, ヨシト and タケシタ, ミツヒロ}
}