{"created":"2023-06-20T13:11:07.940534+00:00","id":194,"links":{},"metadata":{"_buckets":{"deposit":"beea323e-7b1c-44b5-9f17-d7e9cfaf06f5"},"_deposit":{"created_by":15,"id":"194","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"194"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000194","sets":["3:9"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"53","bibliographicPageEnd":"91","bibliographicPageStart":"85","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河野, 奨","creatorNameLang":"ja"},{"creatorName":"カワノ, ススム","creatorNameLang":"ja-Kana"},{"creatorName":"Kawano, Susumu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"伊藤, 里沙","creatorNameLang":"ja"},{"creatorName":"イトウ, リサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Risa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"西山, 美春","creatorNameLang":"ja"},{"creatorName":"ニシヤマ, ミハル","creatorNameLang":"ja-Kana"},{"creatorName":"Nishiyama, Miharu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"久保, 麻衣","creatorNameLang":"ja"},{"creatorName":"クボ, マイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kubo, Mai","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"松島, 知子","creatorNameLang":"ja"},{"creatorName":"マツシマ, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsushima, Tomoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"安保, 明博","creatorNameLang":"ja"},{"creatorName":"アンボ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Ambo, Akihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐々木, 有亮","creatorNameLang":"ja"},{"creatorName":"ササキ, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Yusuke","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Receptor binding properties and antinociceptive activities of chimeric peptides linked by spacers were investigated. The peptides consisted of the μ-opioid receptor ligand dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH_2) or its analog YRFB (Tyr-D-Arg-Phe-βAla-NH_2) linked to the ORL-1 receptor ligand Ac-Arg-Tyr-Tyr-Arg-Ile-Lys-NH_2 (Ac-RYYRIK-NH_2). All chimeric peptides were found to possess high receptor binding affinities for both μ-opioid and ORL-1 receptors in mouse brain membranes. In particular, chimeric peptide 2, which consists of dermorphin and Ac-RYYRIK-NH_2 connected by a long spacer, had high binding affinities toward both receptors. In the tail-flick test following intracerebroventricular (i.c.v.) administration of chimeric peptides containing the YRFB sequence (3 and 4) unexpectedly showed much less potent antinociceptive activity (ED_<5O>>100 pmole/mouse). These results suggest the involvement of nociceptin-like effects of the Ac-RYYRIK pharmacophore in the peptides, and the regulation of μ-opioid receptor-mediated antinociception in brain. The present chimeric peptides (2, 3 and 4) may be useful as pharmacological tools for studies on μ-opioid receptor/ORL-1 receptor heterodimers.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2006-12-01"}],"displaytype":"detail","filename":"KJ00004687280.pdf","filesize":[{"value":"518.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00004687280","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/194/files/KJ00004687280.pdf"},"version_id":"1dd57630-5f17-4fdb-966c-e3a362571f37"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"chimeric peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"u-opioid receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ORL1 receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"receptor binding property","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tail-flick test","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"μ-オピオイド受容体アゴニストとORL-1受容体アンタゴニストから成るキメラペプチドの受容体親和性と鎮痛活性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"μ-オピオイド受容体アゴニストとORL-1受容体アンタゴニストから成るキメラペプチドの受容体親和性と鎮痛活性","subitem_title_language":"ja"},{"subitem_title":"Receptor binding properties and antinociceptive effects of chimeric peptides consisting of a μ-opioid receptor agonist and an ORL-1 receptor antagonist","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-12-01"},"publish_date":"2006-12-01","publish_status":"0","recid":"194","relation_version_is_last":true,"title":["μ-オピオイド受容体アゴニストとORL-1受容体アンタゴニストから成るキメラペプチドの受容体親和性と鎮痛活性"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:50:54.269103+00:00"}