{"created":"2023-06-20T13:11:07.856336+00:00","id":192,"links":{},"metadata":{"_buckets":{"deposit":"bf4a2604-d549-4360-8abc-0c5f2f97f4eb"},"_deposit":{"created_by":15,"id":"192","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"192"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000192","sets":["3:9"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"53","bibliographicPageEnd":"76","bibliographicPageStart":"71","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中山, 大助","creatorNameLang":"ja"},{"creatorName":"ナカヤマ, ダイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakayama, Daisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"渡邉, 廣行","creatorNameLang":"ja"},{"creatorName":"ワタナベ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"藤村, 務","creatorNameLang":"ja"},{"creatorName":"フジムラ, ツトム","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimura, Tsutomu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"櫻田, 忍","creatorNameLang":"ja"},{"creatorName":"サクラダ, シノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakurada, Shinobu","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"We have previously reported that Tyr-D-Pro-Trp-Gly-NH_2 (D-Pro^2-Tyr-W-MIF-1) given spinally produces clearly a dose-dependent attenuation of the antinociception induced by Tyr-W-MIF-1 without affecting endomorphins- and[D-Ala^2, NMePhe^4, Gly(ol)^5]-enkephalin (DAMGO)-induced antinociception, and D-Pro^2-Tyr-W-MIF-1 at any doses used (0.025-1.2 nmol) does not show any antinociception or hyperalgesic effect by itself. In the present study, we found that D-Pro^2-Tyr-W-MIF-1 given supraspinally produced the antinociception, which is mediated by stimulation of μ-opioid receptors. D-Pro^2-Tyr-W-MIF-1 (0.5-16 nmol) given intracerebroventricularly (i.c.v.) produced an apparent dose-dependent antinociception. However, at the three highest doses (4, 8 or 16 nmol), there was a ceiling effect (about 30% MPE) where the increase in dose did not lead to a greater effect. The antinociception induced by D-Pro^2-Tyr-W-MIF-1 at a dose of 4 nmol was blocked by i.c.v. co-administration with the μ-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH_2 (CTOP), but not by i.c.v. pretreatment with the μ_1-opioid receptor antagonist naloxonazine, the κ-opioid receptor antagonist, nor-binaltorphimine, or the δ-opioid receptor antagonist naltrindole. In contrast, the antinociception induced by DAMGO and Tyr-W-MIF-1 was blocked by i.c.v. co-administration with CTOP or by i.c.v. pretreatment with higher doses of naloxonazine, but not by pretreatment with nor-binaltorphimine or naltrindole. We propose that the antinociception induced by D-Pro^2-Tyr-W-MIF-1 and Tyr-W-MIF-1 is mediated by the stimulation of different subtypes of μ_2-opioid receptors.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2006-12-01"}],"displaytype":"detail","filename":"KJ00004687278.pdf","filesize":[{"value":"469.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00004687278","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/192/files/KJ00004687278.pdf"},"version_id":"6b7e4bbe-572d-44fe-9630-39c5d82a769f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antinociception","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"u-Opioid receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"D-Pro^2-Tyr-W-MIF-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tyr-W-MIF-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DAMGO","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tyr-Pro-Trp-Gly-NH_2(Tyr-W-MIF-1)analogであるTyr-D-Pro-Trp-Gly-NH_2の抗侵害作用におけるμオピオイド受容体の関与について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tyr-Pro-Trp-Gly-NH_2(Tyr-W-MIF-1)analogであるTyr-D-Pro-Trp-Gly-NH_2の抗侵害作用におけるμオピオイド受容体の関与について","subitem_title_language":"ja"},{"subitem_title":"Involvement of μ-opioid receptor on the antinociception induced by supraspinal administration of Tyr-D-Pro-Trp-Gly-NH_2","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-12-01"},"publish_date":"2006-12-01","publish_status":"0","recid":"192","relation_version_is_last":true,"title":["Tyr-Pro-Trp-Gly-NH_2(Tyr-W-MIF-1)analogであるTyr-D-Pro-Trp-Gly-NH_2の抗侵害作用におけるμオピオイド受容体の関与について"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:50:56.425628+00:00"}